FERRITIN, A SENSITIZING SUBSTANCE IN THE LEUKOCYTE MIGRATION-INHIBITION TEST IN PATIENTS WITH MALIGNANT-LYMPHOMA

被引：28

作者：

HANCOCK, BW

BRUCE, L

MAY, K

RICHMOND, J

机构：

[1] University of Sheffield, Department of Medicine, Hallamshire Hospital, Sheffield

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 02期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb03745.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary. The nature of the factor in Hodgkin's disease involved spleen to which many patients with malignant lymphoma react in the leucocyte migration inhibition test has been investigated. Our results suggest that ferritin from Hodgkin's disease involved spleens is antigenically different to that prepared from normal spleen. Isoelectric focusing shows the presence of more acidic ‘isoferritins’in ferritin prepared from Hodgkin's disease involved spleen than in that prepared from normal spleen. Further observations using the leucocyte migration inhibition test suggest that sensitization to the abnormal ferritin, acting as an onco‐fetal tumour associated substance, may be responsible for the reaction of patients with malignant lymphoma in this test. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：223 / 233

页数：11

共 24 条

[1] IMMUNORADIOMETRIC ASSAY FOR FERRITIN IN SERUM OF NORMAL SUBJECTS AND PATIENTS WITH IRON-DEFICIENCY AND IRON OVERLOAD [J].