PREJUNCTIONAL MUSCARINIC RECEPTORS ON CHOLINERGIC NERVES IN GUINEA-PIG AIRWAYS ARE OF THE M2-SUBTYPE

被引：18

作者：

DOELMAN, CJA ^{[1
]}

SPRONG, RC ^{[1
]}

NAGTEGAAL, JE ^{[1
]}

DEMIRANDA, JFR ^{[1
]}

BAST, A ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,FAC MED,DEPT PHARMACOL,6500 HB NIJMEGEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 193卷 / 01期

关键词：

SMOOTH MUSCLE (TRACHEAL); MUSCARINIC AUTORECEPTORS; MUSCARINIC-M2; RECEPTORS; (GUINEA-PIG);

D O I：

10.1016/0014-2999(91)90209-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prejunctional inhibitory muscarinic receptors in guinea pig tracheal strips were investigated by electrical field stimulation. Pilocarpine and methacholine caused, in a similar way, a dose-dependent increase in baseline with a concomitant decrease in twitch response. We showed by using selective muscarinic antagonists, such as pirenzepine (M1-selective), methoctramine (M2-selective), AF-DX 116 (11-[[2-[diethylamino)methyl]-l-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one, M2-selective), gallamine (M2-selective) and 4-DAMP (4-diphenylacetoxy-N-methylpiperidinemethiodide, M3-selective), that the prejunctional inhibitory muscarinic receptor is of the M2 subtype.

引用

页码：117 / 119

页数：3

共 9 条

[1] EVIDENCE FOR PREJUNCTIONAL M2 MUSCARINIC RECEPTORS IN PULMONARY CHOLINERGIC NERVES IN THE RAT [J].

AAS, P ;

MACLAGAN, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (01) :73-76

[2] MUSCARINIC RECEPTOR SUBTYPES IN AIRWAYS [J].

BARNES, PJ ;

MINETTE, P ;

MACLAGAN, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (11) :412-416

[3] COMPARISON OF THE MUSCARINIC RECEPTORS OF THE GUINEA-PIG ESOPHAGEAL MUSCULARIS MUCOSAE AND TRACHEA INVITRO [J].

EGLEN, RM ;

WHITING, RL .

JOURNAL OF AUTONOMIC PHARMACOLOGY, 1988, 8 (03) :181-189

[4]

EGLEN RM, 1989, BRIT J PHARMACOL, V98, P449

[5] MUSCARINIC INHIBITORY RECEPTORS IN PULMONARY PARASYMPATHETIC NERVES IN THE GUINEA-PIG [J].

FRYER, AD ;

MACLAGAN, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1984, 83 (04) :973-978

[6] IDENTIFICATION OF M1-MUSCARINIC RECEPTORS IN PULMONARY SYMPATHETIC-NERVES IN THE GUINEA-PIG BY USE OF PIRENZEPINE [J].

MACLAGAN, J ;

FRYER, AD ;

FAULKNER, D .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (02) :499-505

[7] MOLECULAR PHARMACOLOGY OF MUSCARINIC RECEPTOR HETEROGENEITY [J].

MEI, L ;

ROESKE, WR ;

YAMAMURA, HI .

LIFE SCIENCES, 1989, 45 (20) :1831-1851

[8] PREJUNCTIONAL INHIBITORY MUSCARINIC RECEPTORS ON CHOLINERGIC NERVES IN HUMAN AND GUINEA-PIG AIRWAYS [J].

MINETTE, PA ;

BARNES, PJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1988, 64 (06) :2532-2537

[9]

WATSON N, 1989, BRIT J PHARMACOL, V98, pP719

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