NO EFFECT OF THIORIDAZINE ON PLASMA-CONCENTRATIONS OF CARBAMAZEPINE AND ITS ACTIVE METABOLITE CARBAMAZEPINE-10,11-EPOXIDE

被引：4

作者：

SPINA, E

DAGOSTINO, AMA

IOCULANO, MP

OTERI, G

FAZIO, A

PISANI, F

机构：

[1] UNIV MESSINA,NEUROL CLIN 1,I-98100 MESSINA,ITALY

[2] USL 41,HOSP PSYCHIAT,MESSINA,ITALY

来源：

THERAPEUTIC DRUG MONITORING | 1990年 / 12卷 / 05期

关键词：

Carbamazepine; Carbamazepine-10,11 -epoxide; Drug interaction; Thioridazine;

D O I：

10.1097/00007691-199009000-00017

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The effect of an oral treatment with thioridazine (100 or 200 mg daily) on plasma concentrations of carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) was studied in eight epileptic patients stabilized on CBZ therapy. No significant changes in steady-state plasma levels of CBZ and CBZ-E occurred, suggesting that CBZ metabolism is not apparently affected by thioridazine. © 1990 Raven Press, Ltd., New York.

引用

页码：511 / 513

页数：3

共 19 条

[1] CARBAMAZEPINE DRUG-INTERACTIONS [J].