POST-TRANSFUSION PURPURA - THERAPEUTIC FAILURE OF PLA1-NEGATIVE PLATELET TRANSFUSION

The effect of platelet type-specific transfusion in posttransfusion purpura was reported. Seven days after receiving 4 units of whole blood during total hip replacement a 69 yr old woman developed fulminant thrombocytopenic purpura. Her undiluted serum inhibited the clot retraction of PlAl-positive, but not PlAl-negative blood. Anti-PlAl titer of her serum, determined by 51Cr platelet lysis technique, was 1:64. The serum had no lytic activity against platelet-rich plasma from 2 PlAl-negative donors. No anti-HLA antibody was detectable in the serum by lymphocytotoxicity technique and serum obtained prior to transfusions had no platelet lytic activity. Four units of PlAl-negative platelet concentrate were administered, the 1st instance in which this treatment has been used. No rise in platelet count ensued, and the patient succumbed to purpura. Exchange transfusion of plasmapheresis remain the treatments of choice.