DELTA-9-TETRAHYDROCANNABINOL DEPRESSES INWARD SODIUM CURRENT IN MOUSE NEUROBLASTOMA-CELLS

被引：25

作者：

TURKANIS, SA

PARTLOW, LM

KARLER, R

机构：

[1] Department of Pharmacology, University of Utah School of Medicine, Salt Lake City

来源：

NEUROPHARMACOLOGY | 1991年 / 30卷 / 01期

关键词：

DELTA-9-TETRAHYDROCANNABINOL; CANNABINOIDS; WHOLE-CELL VOLTAGE CLAMP; VOLTAGE-GATED SODIUM CURRENT; NEUROBLASTOMA CELL NIE-115;

D O I：

10.1016/0028-3908(91)90045-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Whole-cell voltage-clamp techniques were used in order to define the effects of delta-9-tetrahydrocannabinol (THC) on the voltage-gated sodium current in neuroblastoma cells. With regard to the inward sodium current, THC decreased the peak amplitude and increased both the time to peak and tau for recovery. The reversal potential was unchanged, suggesting that channel selectivity for sodium was not altered by the drug. With regard to the outward sodium current, THC had no effect on the peak amplitude, time to peak or tau for recovery. This functional alteration of the voltage-gated sodium channel may contribute to the depressant effects of the cannabinoid.

引用

页码：73 / 77

页数：5

共 19 条

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