CLEARANCE OF CALCIUM PYROPHOSPHATE DIHYDRATE CRYSTALS INVIVO .1. STUDIES USING YB-169-LABELED TRICLINIC CRYSTALS

被引：28

作者：

MCCARTY, DJ

PALMER, DW

HALVERSON, PB

机构：

[1] Rheumatology Section, Department of Medicine, Medical College of Wisconsin, Milwaukee County General Hospital, Milwaukee, Wisconsin

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 07期

关键词：

D O I：

10.1002/art.1780220705

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Synthetic triclinic calcium pyrophosphate dihydrate crystals were uniformly trace‐labeled with Ytterbium‐169 (169Yb), a pure gamma‐emitting isotope with a halflife of 31 days. The solubility of the labeled crystals was similar to that of cold synthetic crystals. The clearance rate of labeled sterile crystals, sieved to obtain the desired size, was determined after injection of microgram quantities into 4 arthritic human and 3 normal adult rabbit joints and corrected by the observed rate of clearance of free 169Yb. The derived rate constants were then used to calculate the time required for half of the injected dose of CPPD to be cleared from the joint. Crystal clearance was found in all instances. Crystal removal from normal rabbit joints was much more rapid than from the much larger human arthritic joints and was inversely proportional to the size of the crystals injected. Copyright © 1979 American College of Rheumatology

引用

页码：718 / 727

页数：10

共 13 条

[1]

BENEDICT JD, 1949, J BIOL CHEM, V181, P183

[2] FACTORS AFFECTING SOLUBILITY OF CALCIUM PYROPHOSPHATE DIHYDRATE CRYSTALS [J].

BENNETT, RM ;

LEHR, JR ;

MCCARTY, DJ .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (06) :1571-1579

[3] CRYSTAL SHEDDING AND ACUTE PSEUDOGOUT - HYPOTHESIS BASED ON A THERAPEUTIC FAILURE [J].

BENNETT, RM ;

LEHR, JR ;

MCCARTY, DJ .

ARTHRITIS AND RHEUMATISM, 1976, 19 (01) :93-97

[4]

Fiske CH, 1925, J BIOL CHEM, V66, P375

[5]

HALL R. J., 1963, JOUR MED LAB TECHNOL, V20, P97

[6] EXTRUSION OF PYROPHOSPHATE INTO EXTRACELLULAR MEDIA BY OSTEOARTHRITIC CARTILAGE INCUBATES [J].

HOWELL, DS ;

MUNIZ, O ;

PITA, JC ;

ENIS, JE .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (06) :1473-1480

[7]

Lagier R, 1968, 4 S EUR TISS CALC BO, P109

[8] STUDIES ON PATHOLOGICAL CALCIFICATIONS IN HUMAN CARTILAGE .I. PREVALENCE AND TYPES OF CRYSTAL DEPOSITS IN MENISCI OF 215 CADAVERA [J].

MCCARTY, DJ ;

HOGAN, JM ;

GATTER, RA ;

GROSSMAN, M .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1966, A 48 (02) :309-&

[9] SIGNIFICANCE OF CALCIUM PHOSPHATE CRYSTALS IN SYNOVIAL FLUID OF ARTHRITIC PATIENTS - PSEUSOGOUT SYNDROME .1. CLINICAL ASPECTS [J].

MCCARTY, DJ ;

KOHN, NN ;

FAIRES, JS .

ANNALS OF INTERNAL MEDICINE, 1962, 56 (05) :711-+

[10]

MCCARTY DJ, 1964, B RHEUM DIS, V14, P331

← 1 2 →