Transdifferentiation

被引：181

作者：

Eguchi, Goro ^{[1
]}

Kodama, Ryuji ^{[1
]}

机构：

[1] Natl Inst Basic Biol, Div Morphogenesis, Dept Dev Biol, Okazaki, Aichi 444, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 06期

关键词：

D O I：

10.1016/0955-0674(93)90087-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent progress in studies of development and differentiation has greatly stimulated analysis of transdifferentiation, and more cell types capable of transdifferentiation have been documented. Growth factors must be essential, key factors in the regulation of the transdifferentiation process, in cooperation with components of the extracellular matrix, which helps to stabilize the differentiated state of tissues. Trials to induce transdifferentiation artificially by transfection of genes have also begun.

引用

页码：1023 / 1028

页数：6

共 39 条

[1]

AGATA K, 1993, DEVELOPMENT, V118, P1025

[2] TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND TRANSFORMING GROWTH-FACTOR BETA-1 (TGF-BETA-1) STIMULATE FIBRONECTIN SYNTHESIS AND THE TRANSDIFFERENTIATION OF FAT-STORING CELLS IN THE RAT-LIVER INTO MYOFIBROBLASTS [J].

BACHEM, MG ;

SELL, KM ;

MELCHIOR, R ;

KROPF, J ;

ELLER, T ;

GRESSNER, AM .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1993, 63 (02) :123-130

[3] DIRECT TRANSDIFFERENTIATION - CAN CELLS CHANGE THEIR PHENOTYPE WITHOUT DIVIDING [J].

BERESFORD, WA .

CELL DIFFERENTIATION AND DEVELOPMENT, 1990, 29 (02) :81-93

[4] PROGRESSIVE STAGES OF TRANSDIFFERENTIATION FROM EPIDERMAL TO MESENCHYMAL PHENOTYPE INDUCED BY MYOD1 TRANSFECTION, 5-AZA-2'-DEOXYCYTIDINE TREATMENT, AND SELECTION FOR REDUCED CELL ATTACHMENT IN THE HUMAN KERATINOCYTE LINE HACAT [J].

BOUKAMP, P ;

CHEN, J ;

GONZALES, F ;

JONES, PA ;

FUSENIG, NE .

JOURNAL OF CELL BIOLOGY, 1992, 116 (05) :1257-1271

[5] TRANS-DIFFERENTIATION FROM EPIDERMAL TO MESENCHYMAL MYOGENIC PHENOTYPE IS ASSOCIATED WITH A DRASTIC CHANGE IN CELL-CELL AND CELL MATRIX ADHESION MOLECULES [J].

BOUKAMP, P ;

FUSENIG, NE .

JOURNAL OF CELL BIOLOGY, 1993, 120 (04) :981-993

[6]

CICCARONE V, 1989, CANCER RES, V49, P219

[7]

DELISLE RC, 1990, EUR J CELL BIOL, V51, P64

[8] DIFFERENTIATION OF LENS TISSUE FROM PROGENY OF CHICK RETINAL PIGMENT CELLS CULTURED IN-VITRO - DEMONSTRATION OF A SWITCH OF CELL TYPES IN CLONAL CELL-CULTURE - (CYTODIFFERENTIATION-DETERMINATION-LENS REGENERATION EYE) [J].

EGUCHI, G ;

OKADA, TS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (05) :1495-1499

[9]

EGUCHI G, 1992, PROGR RETINAL RES, V12, P205

[10]

EGUCHI G, 1976, CIBA F S, V40, P241

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