FATTY-ACID AMIDES - SCOOTING MODE-BASED DISCOVERY OF TIGHT-BINDING COMPETITIVE INHIBITORS OF SECRETED PHOSPHOLIPASES-A2

被引：50

作者：

JAIN, MK

GHOMASHCHI, F

YU, BZ

BAYBURT, T

MURPHY, D

HOUCK, D

BROWNELL, J

REID, JC

SOLOWIEJ, JE

WONG, SM

MOCEK, U

JARRELL, R

SASSER, M

GELB, MH

机构：

[1] UNIV WASHINGTON,DEPT CHEM,SEATTLE,WA 98195

[2] UNIV WASHINGTON,DEPT BIOCHEM,SEATTLE,WA 98195

[3] STERLING WINTHROP INC,MALVERN,PA 19355

[4] MICROBIAL ID,NEWARK,DE 19711

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 19期

关键词：

D O I：

10.1021/jm00097a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3584 / 3586

页数：3

共 27 条

[1] INTERFACIAL CATALYSIS BY PHOSPHOLIPASE-A2 - DETERMINATION OF THE INTERFACIAL KINETIC RATE CONSTANTS [J].

BERG, OG ;

YU, BZ ;

ROGERS, J ;

JAIN, MK .

BIOCHEMISTRY, 1991, 30 (29) :7283-7297

[2] PURIFICATION OF A 110-KILODALTON CYTOSOLIC PHOSPHOLIPASE-A2 FROM THE HUMAN MONOCYTIC CELL-LINE U937 [J].

CLARK, JD ;

MILONA, N ;

KNOPF, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7708-7712

[3]

CROWL RM, 1991, J BIOL CHEM, V266, P2647

[4] KINETIC CHARACTERIZATION OF PHOSPHOLIPASE-A2 MODIFIED BY MANOALOGUE [J].

GHOMASHCHI, F ;

YU, BZ ;

MIHELICH, ED ;

JAIN, MK ;

GELB, MH .

BIOCHEMISTRY, 1991, 30 (40) :9559-9569

[5]

GLASER KB, 1989, MOL PHARMACOL, V36, P782

[6] INTERFACIAL CATALYSIS BY PHOSPHOLIPASE-A2 - MONOMERIC ENZYME IS FULLY CATALYTICALLY ACTIVE AT THE BILAYER INTERFACE [J].

JAIN, MK ;

RANADIVE, G ;

YU, BZ ;

VERHEIJ, HM .

BIOCHEMISTRY, 1991, 30 (29) :7330-7340

[7] INTERFACIAL CATALYSIS BY PHOSPHOLIPASE-A2 - DISSOCIATION-CONSTANTS FOR CALCIUM, SUBSTRATE, PRODUCTS, AND COMPETITIVE INHIBITORS [J].

JAIN, MK ;

YU, BZ ;

ROGERS, J ;

RANADIVE, GN ;

BERG, OG .

BIOCHEMISTRY, 1991, 30 (29) :7306-7317

[8] ACTIVE-SITE-DIRECTED SPECIFIC COMPETITIVE INHIBITORS OF PHOSPHOLIPASE-A2 - NOVEL TRANSITION-STATE ANALOGS [J].

JAIN, MK ;

TAO, WJ ;

ROGERS, J ;

ARENSON, C ;

EIBL, H ;

YU, BZ .

BIOCHEMISTRY, 1991, 30 (42) :10256-10268

[9] KINETICS OF INTERFACIAL CATALYSIS BY PHOSPHOLIPASE-A2 IN INTRAVESICLE SCOOTING MODE, AND HETEROFUSION OF ANIONIC AND ZWITTERIONIC VESICLES [J].

JAIN, MK ;

ROGERS, J ;

JAHAGIRDAR, DV ;

MARECEK, JF ;

RAMIREZ, F .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 860 (03) :435-447

[10] ACTION OF PHOSPHOLIPASE-A2 ON BILAYERS - EFFECT OF INHIBITORS [J].

JAIN, MK ;

JAHAGIRDAR, DV .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 814 (02) :319-326

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