ANTIOXIDATIVE ACTIVITY OF HIGH-DENSITY-LIPOPROTEINS INVIVO

被引：120

作者：

KLIMOV, AN ^{[1
]}

GUREVICH, VS ^{[1
]}

NIKIFOROVA, AA ^{[1
]}

SHATILINA, LV ^{[1
]}

KUZMIN, AA ^{[1
]}

PLAVINSKY, SL ^{[1
]}

TERYUKOVA, NP ^{[1
]}

机构：

[1] ST PETERSBURG CARDIOL INST,ST PETERSBURG,RUSSIA

来源：

ATHEROSCLEROSIS | 1993年 / 100卷 / 01期

关键词：

HIGH DENSITY LIPOPROTEINS; LIPID PEROXIDATION; CONJUGATED DIENES AND TRIENES;

D O I：

10.1016/0021-9150(93)90063-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study consists of experimental and clinical investigations. It was shown that a single intravenous injection of a large dose of human HDL3 (200 mg protein) to rabbits with induced hypercholesterolemia (plasma cholesterol 500-700 mg/dl) was accompanied by a significant elevation of plasma HDL and led to a decrease (P < 0.05) of conjugated dienes and trienes by 20-30% after 6 h. Conjugated dienes remained stable for 24 h after HDL administration. In the clinical investigations a weak but statistically significant negative correlation (r = 0.262; P = 0.006) between HDL cholesterol and the content of conjugated dienes in the plasma of a total group of healthy subjects and patients with coronary heart disease (CHD) was found. The data allowed us to conclude that, in addition to other antioxidative systems, HDL also take part in the protection of plasma lipids from peroxidation.

引用

页码：13 / 18

页数：6

共 22 条

[1] HEMIN - A POSSIBLE PHYSIOLOGICAL MEDIATOR OF LOW-DENSITY-LIPOPROTEIN OXIDATION AND ENDOTHELIAL INJURY [J].