COMPARATIVE-ANALYSIS OF HTLV-I PROMOTER ACTIVITIES REVEALS NO DISEASE-LINKED PATTERN OF EXPRESSION

被引:12
作者
GONZALEZDUNIA, D [1 ]
KOMURIANPRADEL, F [1 ]
CHIRINIANSYAN, S [1 ]
DETHE, G [1 ]
BRAHIC, M [1 ]
OZDEN, S [1 ]
机构
[1] INST PASTEUR,DEPT RETROVIRUS,UNITES VIRUS LENTS,CNRS,UA 1157,F-75724 PARIS 15,FRANCE
关键词
D O I
10.1089/aid.1993.9.337
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To investigate the possibility of an association between the type of pathology caused by HTLV-I and the activity of its promoter, we compared the levels of transcription obtained with six LTRs isolated from patients with two different HTLV-I-related diseases: ATL and TSP/HAM. The patients came from different geographical endemic areas. The LTR region was amplified by polymerase chain reaction (PCR) from the DNA of uncultured peripheral blood lymphocytes, and directly cloned upstream of the luciferase reporter gene. Constructs were tested by a transient transfection assay in a variety of cell lines. Although the activities of these LTRs were statistically different in some of the cell lines tested, no correlation could be demonstrated between the promoter activity and the nature of the disease. Thus, the data suggest that the LTR is not a major determinant of the nature of the disease associated with the infection by HTLV-I.
引用
收藏
页码:337 / 341
页数:5
相关论文
共 29 条
[1]   ALTERATIONS IN THE U-3 REGION OF THE LONG TERMINAL REPEAT OF AN INFECTIOUS THYMOTROPIC TYPE-B RETROVIRUS [J].
BALL, JK ;
DIGGELMANN, H ;
DEKABAN, GA ;
GROSSI, GF ;
SEMMLER, R ;
WAIGHT, PA ;
FLETCHER, RF .
JOURNAL OF VIROLOGY, 1988, 62 (08) :2985-2993
[2]   GENE-EXPRESSION IN VISNA VIRUS-INFECTION IN SHEEP [J].
BRAHIC, M ;
STOWRING, L ;
VENTURA, P ;
HAASE, AT .
NATURE, 1981, 292 (5820) :240-242
[3]   LONG TERMINAL REPEATS OF HUMAN T-CELL LEUKEMIA VIRUS-II GENOME DETERMINE TARGET-CELL SPECIFICITY [J].
CHEN, ISY ;
MCLAUGHLIN, J ;
GOLDE, DW .
NATURE, 1984, 309 (5965) :276-279
[4]   SEQUENCE VARIANTS OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I FROM PATIENTS WITH TROPICAL SPASTIC PARAPARESIS AND ADULT T-CELL LEUKEMIA DO NOT DISTINGUISH NEUROLOGICAL FROM LEUKEMIC ISOLATES [J].
DAENKE, S ;
NIGHTINGALE, S ;
CRUICKSHANK, JK ;
BANGHAM, CRM .
JOURNAL OF VIROLOGY, 1990, 64 (03) :1278-1282
[5]   NUCLEOTIDE-SEQUENCE ANALYSIS OF A PROVIRUS DERIVED FROM AN INDIVIDUAL WITH TROPICAL SPASTIC PARAPARESIS [J].
EVANGELISTA, A ;
MAROUSHEK, S ;
MINNIGAN, H ;
LARSON, A ;
RETZEL, E ;
HAASE, A ;
GONZALEZDUNIA, D ;
MCFARLIN, D ;
MINGIOLI, E ;
JACOBSON, S ;
OSAME, M ;
SONODA, S .
MICROBIAL PATHOGENESIS, 1990, 8 (04) :259-278
[6]  
GESSAIN A, 1985, LANCET, V2, P407
[7]   FUNCTIONAL-ANALYSIS OF 2 LONG TERMINAL REPEATS FROM THE HTLV-I RETROVIRUS [J].
GONZALEZDUNIA, D ;
CHIRINIANSYAN, S ;
BRAHIC, M ;
OZDEN, S .
GENE, 1992, 116 (02) :151-158
[8]  
HAASE A, 1990, HUMAN RETROVIROLOGY : HTLV, P15
[9]   DELETED HTLV-I PROVIRUS IN BLOOD AND CUTANEOUS LESIONS OF PATIENTS WITH MYCOSIS-FUNGOIDES [J].
HALL, WW ;
LIU, CRR ;
SCHNEEWIND, O ;
TAKAHASHI, H ;
KAPLAN, MH ;
ROUPE, G ;
VAHLNE, A .
SCIENCE, 1991, 253 (5017) :317-320
[10]   ADULT T-CELL LEUKEMIA - ANTIGEN IN AN ATL CELL-LINE AND DETECTION OF ANTIBODIES TO THE ANTIGEN IN HUMAN-SERA [J].
HINUMA, Y ;
NAGATA, K ;
HANAOKA, M ;
NAKAI, M ;
MATSUMOTO, T ;
KINOSHITA, KI ;
SHIRAKAWA, S ;
MIYOSHI, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6476-6480