CHANGES IN CYTOKINE PRODUCTION DURING THERAPY WITH GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN PATIENTS WITH CHRONIC HEPATITIS-B

被引：13

作者：

MARTIN, J ^{[1
]}

QUIROGA, JA ^{[1
]}

BOSCH, O ^{[1
]}

CARRENO, V ^{[1
]}

机构：

[1] FDN JIMENEZ DIAZ,UNIDAD HEPATOL,E-28040 MADRID,SPAIN

来源：

HEPATOLOGY | 1994年 / 20卷 / 05期

关键词：

D O I：

10.1016/0270-9139(94)90751-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recombinant human granulocyte-macrophage colony-stimulating factor therapy significantly reduces serum hepatitis B virus DNA levels, associated with increased 2',5'-oligoadenylate synthetase activity in cultured mononuclear cells of patients with chronic hepatitis B. To assess changes in immune function during therapy of chronic hepatitis B patients, spontaneous and mitogen-induced production of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interferon-alpha and interferon-gamma were measured-along with serum levels of soluble CD4, soluble CD8, soluble interleukin-2 receptor and beta 2-microglobulin-before, during and after a 6-wk course of granulocyte-macrophage colony-stimulating factor in nine patients with chronic hepatitis B. Treatment statistically enhanced spontaneous production of tumor necrosis factor-alpha (p < 0.05) and interleukin-1 beta (p < 0.02). Furthermore, spontaneous interleukin-6 production correlated negatively with hepatitis B virus DNA levels (p < 0.03), and spontaneous interleukin-1 beta production correlated positively with 2',5'-oligoadenylate synthetase activity (p < 0.0005). In addition, statistically significant increases were found during therapy in serum levels of soluble interleukin-2 receptor (p < 0.01), soluble CD4 (p < 0.01) and beta 2-microglobulin (p < 0.05). Levels of soluble interleukin-2 receptor and soluble CD4 correlated negatively with levels of hepatitis B virus DNA (p < 0.05), and levels of soluble interleukin-2 receptor and beta 2-microglobulin correlated positively with 2',5'oligoadenylate synthetase activity (p < 0.003 and p < 0.02, respectively). Thus recombinant human granulocyte-macrophage colony-stimulating factor administration may induce reductions in hepatitis B virus DNA levels, perhaps by altering the immune status and increasing cytokine production.

引用

页码：1156 / 1161

页数：6

共 17 条

[1] HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR INDUCES EXPRESSION OF THE TUMOR-NECROSIS-FACTOR GENE BY THE U937 CELL-LINE AND BY NORMAL HUMAN-MONOCYTES [J].