ACETYLCHOLINE RECEPTOR - COVALENT ATTACHMENT OF DEPOLARIZING GROUPS AT ACTIVE SITE

被引：100

作者：

SILMAN, I

KARLIN, A

机构：

来源：

SCIENCE | 1969年 / 164卷 / 3886期

关键词：

D O I：

10.1126/science.164.3886.1420

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Following reduction of the acetylcholine receptor in the electroplax with dithiothreitol, the quaternary ammonium compounds bromoacetylcholine bromide and the p-nitrophenyl ester of (p-carboxyphenyl) trimethylammonium iodide react near the active site probably with a sulfhydryl group. The covalently attached quaternary ammonium moieties additionally interact with the active site noncovalently to activate the receptor and cause depolarization of the cell.

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页码：1420 / &

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