DETERMINATION OF THE FREQUENCY OF THE A2M (2) ALLELE OF IMMUNOGLOBULINS-A IN TUNISIAN POPULATION USING RFLP TECHNIQUE

被引：2

作者：

FAKHFAKH, F ^{[1
]}

ROUIS, S ^{[1
]}

MAKNI, H ^{[1
]}

AYADI, H ^{[1
]}

机构：

[1] FAC MED SFAX,IMMUNOL LAB,SFAX,TUNISIA

来源：

REVUE FRANCAISE DE TRANSFUSION ET D HEMOBIOLOGIE | 1991年 / 34卷 / 06期

关键词：

D O I：

10.1016/S1140-4639(05)80138-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human IgA2 subclass has two allotypes A2m(1) and A2m (2). Using the RFLP technique, we determined the A2m(2) frequency in a sample of 29 tunisian individuals. In accordance with Lefranc and all. [6], the presence of a polymorphic EcoRI site of the A2m(2) allele was confirmed in our RFLP study whereas no BamHI nor HindIII polymorphisms were shown. Among the 29 cases studies, 11 were heterozygous A2m2-1, 17 homozygous A2m1-1 and 1 homozygous A2m2-2. The A2m2 allele frequency in the Tunisian population (0,22) is intermediate between the Europeen frequency and the African one.

引用

页码：441 / 447

页数：7

共 12 条

[1]

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[2]

BENSMANA M, 1990, REUNION SFI, P97

[3]

CHINGWIN JM, 1979, BIOCHEMISTRY-US, V18, P5294

[4] MECHANISMS OF DIVERGENCE AND CONVERGENCE OF THE HUMAN-IMMUNOGLOBULIN ALPHA-1 AND ALPHA-2 CONSTANT REGION GENE-SEQUENCES [J].