DETECTION OF AN AUTOANTIBODY DIRECTED AGAINST HUMAN LIVER MICROSOMAL PROTEIN IN A PATIENT WITH CARBAMAZEPINE HYPERSENSITIVITY

被引：41

作者：

PIRMOHAMED, M ^{[1
]}

KITTERINGHAM, NR ^{[1
]}

BRECKENRIDGE, AM ^{[1
]}

PARK, BK ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,POB 147,LIVERPOOL L69 3BX,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 02期

基金：

英国惠康基金;

关键词：

CARBAMAZEPINE; TOXICITY; HYPERSENSITIVITY; AUTOANTIBODY;

D O I：

10.1111/j.1365-2125.1992.tb04022.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A 16-year old patient with carbamazepine-induced hepatotoxicity, associated with the hypersensitivity manifestations of fever, rash and eosinophilia, is described. Mononuclear leucocytes from the patient were more sensitive to oxidative metabolites of carbamazepine generated by induced murine and human hepatic microsomes, than cells from controls. On immunoblot analysis, serum from the patient recognised a single protein band (94 kDa) on human liver microsomes, but none out of 25 control sera recognised this band. No bands were recognised by the patient serum on human kidney microsomes or on microsomes from mouse and rat liver.

引用

页码：183 / 186

页数：4

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