STUDIES OF THE RAD-EQUIVALENCE OF ETHYLENE-OXIDE IN THE PRESENCE AND ABSENCE OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) IN C3H/10T1/2 CELLS

被引：7

作者：

KOLMAN, A

NASLUND, M

OSTERMANGOLKAR, S

机构：

[1] Department of Radiobiology, Stockholm University

来源：

TOXICOLOGY LETTERS | 1990年 / 53卷 / 03期

关键词：

12-O-tetradecanoyl-phorbol-13-acetate (TPA); Ethylene oxide; Rad-equivalence;

D O I：

10.1016/0378-4274(90)90235-E

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cell transformation in vitro of C3H/10T1/2 cells, using gamma-radiation and ethylene oxide (EtO), in both the absence and presence of the cancer promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), was studied. TPA promotes transformation of C3H/10T1/2 cells to the same extent. In the dose ranges studied the average enhancement of the transformation frequency was 2.4 and 2.5 for EtO and gamma-radiation, respectively. The rad-equivalence of EtO in the presence of TPA was calculated to be 75 ±52 rad mMh (95% confidence interval) which is consistent with the value 78 ± 14 rad mMh (95% confidence interval) obtained without TPA treatment. © 1990.

引用

页码：307 / 313

页数：7

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