SYNTHESIS OF C-14 AND TRITIUM ANALOGS OF THE PHOSPHOLIPID ANTITUMOR AGENT SDZ 62-834 ZI

被引：3

作者：

KINDER, FR

TANG, YS

SUNAY, UB

机构：

[1] Isotope Laboratories, Chemical Research and Development Sandoz Research Institute, E. Hanover, New Jersey

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 10期

关键词：

PHOSPHOLIPID; TETRAHYDROFURAN; C-14; TRITIUM; RHODIUM CARBENOID;

D O I：

10.1002/jlcr.2580311013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

2-[[Hydroxyl[[tetrahydro-2-[(octadecyloxy)methyl]-2-furanyl)]methoxy)phosphinyl]oxy]-N, N, N-trimethylethanaminium hydroxide inner salt (SDZ 62-834 zi) was synthesized with carbon-14 at the furan-2 position from dimethyl malonate-[C-14]. In addition, SDZ 62-834 zi was also synthesized with tritium at the furan 3 and 4 positions by catalytic tritiation of 2,5-dihydro-2,2-furandimethanol.

引用

页码：829 / 835

页数：7

共 6 条

[1] RHODIUM (II) CATALYZED-REACTIONS OF DIAZO-CARBONYL COMPOUNDS [J].