BENASTATIN-A AND BENASTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 .1. TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES

被引：39

作者：

AOYAGI, T ^{[1
]}

AOYAMA, T ^{[1
]}

KOJIMA, F ^{[1
]}

MATSUDA, N ^{[1
]}

MARUYAMA, M ^{[1
]}

HAMADA, M ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] SHOWA COLL PHARMACEUT SCI, MACHIDA, TOKYO 194, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 09期

关键词：

D O I：

10.7164/antibiotics.45.1385

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Benastatins have been isolated as part of a program designed to find microorganism-produced inhibitors of glutathione S-transferase from Streptomyces sp. MI384-DF12. They were purified by chromatography of reversed-phase silica gel, silica gel and Capcell Pak C18 (HPLC) followed by solvent extraction and then isolated as yellow powders. Benastatins A and B have the molecular formulae, C30H28O7 and C30H30O7, respectively. They were competitive with 3,4-dichloronitrobenzene as the substrate, and the inhibition constants (Ki) of benastatins A and B were 5.0 x 10(-6) and 3.7 x 10(-6), respectively.

引用

页码：1385 / 1390

页数：6

共 7 条

[1] AOYAMA T, 1992, ANTIBIOTICS, V45, P1391
[2] HABIG WH, 1974, J BIOL CHEM, V249, P7130
[3] DETOXICATION REACTIONS OF GLUTATHIONE AND GLUTATHIONE TRANSFERASES
KETTERER, B
[J]. XENOBIOTICA, 1986, 16 (10-11) : 957 - 973
[4] SELECTIVE-INHIBITION OF LEUKOTRIENE-C4 SYNTHESIS IN HUMAN-NEUTROPHILS BY ETHACRYNIC-ACID
LEUNG, KH
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (01) : 195 - 200
[5] SATO K, 1989, ADV CANCER RES, V52, P205
[6] SHIRLING E. B., 1966, INT J SYST BACTERIOL, V16, P313
[7] INDOMETHACIN INHIBITION OF GLUTATHIONE S-TRANSFERASES
WU, C
MATHEWS, KP
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 112 (03) : 980 - 985

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