DIETARY FISH-OIL ALTERS RAT MILK-COMPOSITION AND LIVER AND BRAIN FATTY-ACID COMPOSITION OF FETAL AND NEONATAL RATS

被引:36
作者
YONEKUBO, A
HONDA, S
OKANO, M
TAKAHASHI, K
YAMAMOTO, Y
机构
[1] Meiji Central Research Institute, Meiji Milk Products, Higashimurayamashi, Tokyo 189
关键词
DOCOSAHEXAENOIC ACID; MILK COMPOSITION; RATS; FETUS; TISSUE PHOSPHOLIPIDS;
D O I
10.1093/jn/123.10.1703
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
This study was performed to determine the effects of dietary fish oil rich in docosahexaenoic acid [22:6(n-3)] on the milk-composition of maternal rats and tissue fatty acid composition of fetal and neonatal rats. The fatty acid composition of dam's milk was affected by the dietary fat. The level of 22: 6(n-3) in the milk of dams fed the fish oil-containing diet was severalfold higher than that of dams fed the diet that did not contain fish oil, and the levels of 22: 6(n-3) in the phospholipids of the livers and brains of fetuses and pups of the fish oil-fed group were higher than those in fetuses and pups of the group that did not receive fish oil. These findings suggest that a high level of 22:6(n-3) in the livers and brains of fetal and neonatal rats can be achieved by intake of fish oil by the dams.
引用
收藏
页码:1703 / 1708
页数:6
相关论文
共 22 条
[1]   EFFECTS OF DIETARY LINOLENATE ON THE FATTY-ACID COMPOSITION OF BRAIN LIPIDS IN RATS [J].
ANDING, RH ;
HWANG, DH .
LIPIDS, 1986, 21 (11) :697-701
[2]   EFFECT OF FISH OIL SUPPLEMENTATION ON THE N-3 FATTY-ACID CONTENT OF RED-BLOOD-CELL MEMBRANES IN PRETERM INFANTS [J].
CARLSON, SE ;
RHODES, PG ;
RAO, VS ;
GOLDGAR, DE .
PEDIATRIC RESEARCH, 1987, 21 (05) :507-510
[3]   EFFECT OF DIETARY N-3 POLY-UNSATURATED FATTY-ACIDS ON CHOLESTEROL-SYNTHESIS AND DEGRADATION IN RATS OF DIFFERENT AGES [J].
CHOI, YS ;
GOTO, S ;
IKEDA, I ;
SUGANO, M .
LIPIDS, 1989, 24 (01) :45-50
[4]  
CONNOR WE, 1990, J LIPID RES, V31, P237
[5]   ESSENTIAL FATTY-ACID REQUIREMENTS IN INFANCY [J].
CRAWFORD, MA ;
HASSAM, AG ;
RIVERS, JPW .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1978, 31 (12) :2181-2185
[6]  
FOLCH J, 1951, J BIOL CHEM, V191, P833
[7]   FATTY-ACID COMPOSITION OF HUMAN COLOSTRUM AND MATURE BREAST-MILK [J].
GIBSON, RA ;
KNEEBONE, GM .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1981, 34 (02) :252-257
[8]  
GOODNIGHT SH, 1990, AM J CLIN NUTR, V51, P399
[9]   THIN-LAYER CHROMATOGRAPHY OF HUMAN-PLATELET PHOSPHOLIPIDS WITH FATTY-ACID ANALYSIS [J].
LERAY, C ;
PELLETIER, X ;
HEMMENDINGER, S ;
CAZENAVE, JP .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 420 (02) :411-416
[10]   THE INFLUENCE OF DIETARY MANIPULATION WITH N-3 AND N-6 FATTY-ACIDS ON LIVER AND PLASMA PHOSPHOLIPID FATTY-ACIDS IN RATS [J].
NASSAR, BA ;
HUANG, YS ;
MANKU, MS ;
DAS, UN ;
MORSE, N ;
HORROBIN, DF .
LIPIDS, 1986, 21 (10) :652-656