PAC-1 - A MITOGEN-INDUCED NUCLEAR-PROTEIN TYROSINE PHOSPHATASE

被引：291

作者：

ROHAN, PJ

DAVIS, P

MOSKALUK, CA

KEARNS, M

KRUTZSCH, H

SIEBENLIST, U

KELLY, K

机构：

[1] NCI,PATHOL LAB,BETHESDA,MD 20892

[2] NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1993年 / 259卷 / 5102期

关键词：

D O I：

10.1126/science.7681221

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tyrosine phosphorylation of proteins is required for signal transduction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.

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页码：1763 / 1766

页数：4

相关论文

共 23 条

[1] THE ALLANTOINASE (DAL1) GENE OF SACCHAROMYCES-CEREVISIAE [J].

BUCKHOLZ, RG ;

COOPER, TG .

YEAST, 1991, 7 (09) :913-923

[2] THE INTERLEUKIN-2 T-CELL SYSTEM - A NEW CELL-GROWTH MODEL [J].

CANTRELL, DA ;

SMITH, KA .

SCIENCE, 1984, 224 (4655) :1312-1316

[3] HUMAN-PLACENTA PROTEIN-TYROSINE-PHOSPHATASE - AMINO-ACID SEQUENCE AND RELATIONSHIP TO A FAMILY OF RECEPTOR-LIKE PROTEINS [J].

CHARBONNEAU, H ;

TONKS, NK ;

KUMAR, S ;

DILTZ, CD ;

HARRYLOCK, M ;

COOL, DE ;

KREBS, EG ;

FISCHER, EH ;

WALSH, KA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5252-5256

[4]

CHARLES CH, 1992, ONCOGENE, V7, P187

[5]

DAVIS P, UNPUB

[6] PROTEIN TYROSINE PHOSPHATASES - A DIVERSE FAMILY OF INTRACELLULAR AND TRANSMEMBRANE ENZYMES [J].

FISCHER, EH ;

CHARBONNEAU, H ;

TONKS, NK .

SCIENCE, 1991, 253 (5018) :401-406

[7] A TYR SER PROTEIN PHOSPHATASE ENCODED BY VACCINIA VIRUS [J].

GUAN, KL ;

BROYLES, SS ;

DIXON, JE .

NATURE, 1991, 350 (6316) :359-362

[8] ISOLATION AND CHARACTERIZATION OF FULL-LENGTH CDNA CLONES FOR HUMAN ALPHA-ACTIN, BETA-ACTIN AND GAMMA-ACTIN MESSENGER-RNAS - SKELETAL BUT NOT CYTOPLASMIC ACTINS HAVE AN AMINO-TERMINAL CYSTEINE THAT IS SUBSEQUENTLY REMOVED [J].

GUNNING, P ;

PONTE, P ;

OKAYAMA, H ;

ENGEL, J ;

BLAU, H ;

KEDES, L .

MOLECULAR AND CELLULAR BIOLOGY, 1983, 3 (05) :787-795

[9] PRIMARY RESPONSE GENES INDUCED BY GROWTH-FACTORS AND TUMOR PROMOTERS [J].

HERSCHMAN, HR .

ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :281-319

[10] MITOGEN-INDUCED GENES ARE SUBJECT TO MULTIPLE PATHWAYS OF REGULATION IN THE INITIAL-STAGES OF T-CELL ACTIVATION [J].

IRVING, SG ;

JUNE, CH ;

ZIPFEL, PF ;

SIEBENLIST, U ;

KELLY, K .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (03) :1034-1040