INTERACTION BETWEEN TOLBUTAMIDE AND KETOCONAZOLE IN HEALTHY-SUBJECTS

被引：30

作者：

KRISHNAIAH, YSR ^{[1
]}

SATYANARAYANA, S ^{[1
]}

VISWESWARAM, D ^{[1
]}

机构：

[1] ANDHRA UNIV,DEPT PHARMACEUT SCI,VISAKHAPATNAM 530003,INDIA

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 37卷 / 02期

关键词：

TOLBUTAMIDE; KETOCONAZOLE; INTERACTION;

D O I：

10.1111/j.1365-2125.1994.tb04262.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A possible interaction between tolbutamide and ketoconazole was studied in seven healthy volunteers. Treatment for 1 week with 200 mg oral ketoconazole increased the elimination half-life (from mean +/- s.d. 3.7 +/- 0.4 to 12.3 +/- 1.9 h) and AUC(0,12 h) of tolbutamide (from 309 +/- 27 to 546 +/- 20 mu g m1(-1) h) by 25 +/- 64 and 66 +/- 15%, respectively. The percentage blood glucose reduction was also increased when tolbutamide and ketoconazole were coadministered.

引用

页码：205 / 207

页数：3

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