BREAKTHROUGH INFECTIONS AND IDENTIFICATION OF A VIRAL VARIANT IN GAMBIAN CHILDREN IMMUNIZED WITH HEPATITIS-B VACCINE

被引:72
作者
FORTUIN, M
KARTHIGESU, V
ALLISON, L
HOWARD, C
HOARE, S
MENDY, M
WHITTLE, HC
机构
[1] MRC LABS, BANJUL, GAMBIA
[2] INT AGCY RES CANC, GAMBIA HEPATITIS INTERVENT STUDY, BANJUL, GAMBIA
[3] UNIV LONDON ROYAL VET COLL, DEPT PATHOL & INFECT DIS, LONDON, ENGLAND
[4] MRC, DUNN NUTR LABS, CAMBRIDGE, ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1093/infdis/169.6.1374
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Hepatitis B (HB) breakthrough infections, identified by the presence of HB core (c) antibody, were found in 32 of 358 Gambian children vaccinated with plasma-derived HB vaccine. Over 2 years, 15 of these children lost their HBc antibodies. These children had significantly higher HB surface antibody levels before infection than those who retained HBc antibodies. One child, who responded well to the vaccine, had HB viral DNA detected in the presence of HBs antibodies. The S gene sequence of this DNA showed nucleotide changes that resulted in an amino acid substitution at residue 141 (lysine to glutamic acid) of the surface antigen. This finding suggests the child was infected with a variant virus that was not neutralized by antibodies resulting from HB vaccination.
引用
收藏
页码:1374 / 1376
页数:3
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