ASSOCIATION OF ALCOHOL INTAKE, CIGARETTE-SMOKING, AND OCCUPATIONAL-STATUS WITH THE RISK OF IDIOPATHIC OSTEONECROSIS OF THE FEMORAL-HEAD

被引:155
作者
HIROTA, Y
HIROHATA, T
FUKUDA, K
MORI, M
YANAGAWA, H
OHNO, Y
SUGIOKA, YI
机构
[1] KURUME UNIV,SCH MED,DEPT PUBL HLTH,KURUME,JAPAN
[2] SAPPORO MED COLL,DEPT PUBL HLTH,SAPPORO,HOKKAIDO 060,JAPAN
[3] JICHI MED SCH,SCH MED,DEPT PUBL HLTH,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
[4] NAGOYA UNIV,SCH MED,DEPT PREVENT MED,NAGOYA,AICHI 466,JAPAN
[5] KYUSHU UNIV,SCH MED,DEPT ORTHOPED SURG,FUKUOKA 812,JAPAN
关键词
ALCOHOL DRINKING; FEMUR HEAD NECROSIS; OCCUPATIONS; SMOKING;
D O I
10.1093/oxfordjournals.aje.a116706
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To investigate the association of alcohol intake, cigarette smoking, occupation, and other factors with the development of idiopathic osteonecrosis of the femoral head, a nationwide multicenter case-control study was conducted in Japan during 1988-1990, comparing 118 cases with no history of systemic corticosteroid use with 236 controls matched for sex, age, ethnicity, clinic, and date of initial examination. The risks of developing femoral head necrosis associated with potential risk factors were estimated by adjusted relative odds obtained by a conditional logistic regression model. The elevated relative odds were observed for occasional drinkers (relative odds = 3.2, 95% confidence interval 1.1-9.2) and regular drinkers (relative odds = 13.1, 95% confidence interval 4.1-42.5) with a significant dose-response relation (p < 0.001). For current drinkers, the relative odds were 2.8. 9.4, and 14.8 for <320, 320-799, and greater-than-or-equal-to 800 g/week of ethanol intake, respectively. An increased risk was found for current smokers (relative odds = 4.7, 95% confidence interval 1.5-14.5), but a linear increasing trend in the cumulative effect of smoking was not evident at 20 pack-years or over. A weak but significant dose-response relation was observed for daily occupational energy consumption (p < 0.05). The present study confirmed the strong association of alcohol intake and positive association of cigarette smoking and suggested the role of heavy physical work.
引用
收藏
页码:530 / 538
页数:9
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