GENERAL PHARMACOLOGICAL STUDIES OF FUSARENON-X, A TRICHOTHECENE MYCOTOXIN FROM FUSARIUM SPECIES

被引:33
作者
MATSUOKA, Y
KUBOTA, K
UENO, Y
机构
[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Shinjuku-ku, Tokyo, 162, 12, Ichigaya-funagawara-cho
关键词
D O I
10.1016/0041-008X(79)90495-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Fusarenon-X (F-X) is one of the trichothecene mycotoxins. In the present work, pharmacological properties of F-X were examined. (1) F-X induced hypothermia but did not produce appreciable behavioral changes of mice. (2) In anesthetized rats, F-X caused a rise in the blood pressure and a decrease in the respiratory rate but induced no significant change in the heart rate. (3) In isolated tissues such as fundus muscle, vas deferens, tracheal muscle, ileum, and atrium, F-X had no detectable effects on spontaneous activity and the responsiveness to agonists. (4) Subplantar administration of F-X into rat hindpaw induced edema. F-X had little influence on the histamine release from mast cells and the membrane stability of erythrocytes. (5) F-X decreased the spontaneous peristalsis of intestine but increased the intestinal propulsion of charcoal meal. (6) F-X induced vomiting in dogs which was suppressed by preliminary administration of chlorpromazine and metoclopramide. F-X may induce vomiting by stimulating the chemoreceptor trigger zone in dogs. © 1979.
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页码:87 / 94
页数:8
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