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IDENTIFICATION OF MURINE ENDOGENOUS XENOTROPIC RETROVIRUS IN CULTURED MULTICELLULAR TUMOR SPHEROIDS FROM NUDE-MOUSE-PASSAGED NASOPHARYNGEAL CARCINOMA

被引：18
作者：
CRAWFORD, DH
ACHONG, BG
TEICH, NM
FINERTY, S
THOMPSON, JL
EPSTEIN, MA
GIOVANELLA, BC
机构：
[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND
[2] ST JOSEPH HOSP,CANC RES LAB,HOUSTON,TX 77002
来源：
INTERNATIONAL JOURNAL OF CANCER | 1979年 / 23卷 / 01期
关键词：
D O I：
10.1002/ijc.2910230102
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
After nude‐mouse‐passage, a carcinoma of the nasopharynx was found to contain a few scattered C‐t/pe retrovirus particles. Culture of this nude‐mouse‐grown material over solid agar allowed the human tumour cells to grow as multicellular spheroids which increased in number by budding and could be subcultured for up to 6 months. Within the spheroids the human tumour cells expressed increased retrovirus replication and large numbers of C‐type particles were observed. Treatment with a halogenated pyrimidine further enhanced the virus production. This tissue culture system provided sufficient virus production for the identification of the retrovirus as an endogenous xenotropic murine leukaemia virus and not a human agent. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
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页码：1 / 7
页数：7
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