Coordination of glucose and glutamine utilization by an expanded Myc network

被引：26

作者：

Kaadige, Mohan R. ^{[1
]}

Elgort, Marc G. ^{[1
]}

Ayer, Donald E. ^{[1
]}

机构：

[1] Univ Utah, Dept Oncol Sci, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

TRANSCRIPTION-AUSTIN | 2010年 / 1卷 / 01期

关键词：

glucose; glutamine; nutrient; mitochondria; MondoA; Myc; TXNIP;

D O I：

10.4161/trns.1.1.12142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucose and glutamine are the most abundant circulating nutrients and support the growth and proliferation of all cells, in particular rapidly growing and dividing cancer cells. Several recent studies implicate an expanded Myc network in how cells sense and utilize both glucose and glutamine. These studies reveal an unappreciated coordination between glycolysis and glutaminolysis, potentially providing new targets for therapeutic intervention in cancer.

引用

页码：36 / 40

页数：5

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