DESIGN AND SYNTHESIS OF BIOCOMPATIBLE POLYMERIC MATERIALS

被引：20

作者：

IMANISHI, Y

ITO, Y

LIU, LS

KAJIHARA, M

机构：

[1] Kyoto Univ, Japan

来源：

JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY | 1988年 / A25卷 / 5-7期

关键词：

Biomaterials--Synthesis - Enzymes--Immobilization - Proteins - Silicones--Thin Films;

D O I：

10.1080/00222338808053384

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

One approach to antithrombogenic materials, the combination of synthetic polymers with physiologically active substances, seems to be promising. This involves crosslinked urokinase (HM-UK), in which urokinases are linked with side chains of poly(2-hydroxyethyl methacrylate)(PHEMA) by 4,4′-diisocyanatodiphenyl-methane, and encapsulated urokinase (HMe-UK), in which urokinases are encapsulated in the network of crosslinked PHEMA. The HMe-UK with a low degree of crosslinking was found to be highly antithrombogenic.

引用

页码：555 / 570

页数：16

共 18 条

[1] BURKEL WE, 1981, J SURG RES, V30, P305, DOI 10.1016/0022-4804(81)90165-7
[2] CHICK WL, 1975, T AM SOC ART INT ORG, V21, P8
[3] MONITORING OF REACTIONS IN SOLID-PHASE PEPTIDE SYNTHESIS WITH PICRIC ACID
GISIN, BF
[J]. ANALYTICA CHIMICA ACTA, 1972, 58 (01) : 248 - &
[4] IGUCHI Y, 1986, 8TH ANN M JAP SOC BI
[5] NEW METHOD FOR EVALUATION OF ANTITHROMBOGENICITY OF MATERIALS
IMAI, Y
NOSE, Y
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1972, 6 (03): : 165 - &
[6] SYNTHESIS AND ANTITHROMBOGENICITY OF ANIONIC POLYURETHANES AND HEPARIN-BOUND POLYURETHANES
ITO, Y
SISIDO, M
IMANISHI, Y
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1986, 20 (08): : 1157 - 1177
[7] SYNTHESIS AND ANTITHROMBOGENICITY OF POLYETHERURETHANEUREA CONTAINING QUATERNARY AMMONIUM GROUPS IN THE SIDE-CHAINS AND OF THE POLYMER HEPARIN COMPLEX
ITO, Y
SISIDO, M
IMANISHI, Y
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1986, 20 (07): : 1017 - 1033
[8] ITO Y, IN PRESS BIOMATERIAL
[9] JOHNSON AJ, 1969, THROMB DIATH HAEMOST, V21, P259
[10] LIU LS, 1986, POLYM PREPR JPN, V35, P536

← 1 2 →