INCREASED LEVEL OF HISTONE H1 MESSENGER-RNA IN HYPOXIC EHRLICH ASCITES TUMOR-CELLS

被引：7

作者：

BOUTERFA, H

DOENECKE, D

LOFFLER, M

机构：

[1] UNIV GOTTINGEN,INST BIOCHEM,HUMBOLDTALLEE 23,W-3400 GOTTINGEN,GERMANY

[2] UNIV MARBURG,INST THEORET MED,W-3550 MARBURG,GERMANY

来源：

EXPERIMENTAL CELL RESEARCH | 1990年 / 188卷 / 01期

关键词：

D O I：

10.1016/0014-4827(90)90292-I

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the expression of the H1 histone subtype H10 gene in Ehrlich ascites tumor cells (EAT) under varied conditions of oxygen supply. Our results show that proliferating EAT cells express H10 mRNA at a basal level under normoxic conditions. Severe hypoxia leads to a cessation of cell growth and causes an accumulation of cells in G1. Here, we show that the level of H10 histone mRNA increases within a few hours after the Onset Of hypoxia. © 1990.

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页码：160 / 163

页数：4

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