THIOPENTAL EFFICACY IN PHENOBARBITAL-RESISTANT NEONATAL SEIZURES

被引：8

作者：

BONATI, M ^{[1
]}

MARRARO, G ^{[1
]}

CELARDO, A ^{[1
]}

PASSERINI, F ^{[1
]}

SCHIERONI, F ^{[1
]}

SPADA, P ^{[1
]}

VALSECCHI, R ^{[1
]}

DECAPITANI, E ^{[1
]}

机构：

[1] HOSP MERATE,DEPT ANESTHESIOL & INTENS CARE,MERATE,ITALY

来源：

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS | 1990年 / 15卷 / 01期

关键词：

asphyxia; neonatal seizures; newborns; phenobarbital; thiopental pharmacokinetics;

D O I：

10.1159/000457614

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The successful treatment with thiopental (10 mg/kg, i.v.) of 9 severely asphyxiated newborns, under artificial ventilation, with neonatal seizures resistant to phenobarbital, is reported in this pilot study. The clinical and electroencephalogram control of seizures was prompt and resolute. No adverse effect on cardiovascular function (heart rate, blood presssure) was observed. The terminal half-life of thiopental averaged 9 h, the total plasma clearance 0.20 1/h/kg, and the steady-state volume of distribution 3.6 1/h/kg. The kinetic profile of the drug compared to phenobarbital and phenytoin in newborns suggests that its action is quicker and shorter lasting. Thus, from these findings, thiopental may offer a useful and handy approach for the safe and effective treatment of phenobarbital-resistant neonatal seizures.

引用

页码：16 / 20

页数：5

共 18 条

[1] OUTCOME IN NEONATES WITH CONVULSIONS TREATED IN AN INTENSIVE-CARE UNIT [J].

BERGMAN, I ;

PAINTER, MJ ;

HIRSCH, RP ;

CRUMRINE, PK ;

DAVID, R .

ANNALS OF NEUROLOGY, 1983, 14 (06) :642-647

[2] NEONATAL SEIZURES - A SURVEY OF CURRENT PRACTICE [J].

BOER, HR ;

GAL, P .

CLINICAL PEDIATRICS, 1982, 21 (08) :453-457

[3]

CELARDO A, IN PRESS J CHROMATOG

[4] NEONATAL SEIZURES - THE DUBLIN COLLABORATIVE STUDY [J].

CURTIS, PD ;

MATTHEWS, TG ;

CLARKE, TA ;

DARLING, M ;

CROWLEY, P ;

GRIFFIN, E ;

OCONNELL, P ;

GORMAN, W ;

OBRIEN, N ;

OHERLIHY, C ;

OREGAN, M .

ARCHIVES OF DISEASE IN CHILDHOOD, 1988, 63 (09) :1065-1068

[5] HIGH-DOSE THIOPENTAL PHARMACOKINETICS IN BRAIN-INJURED CHILDREN AND NEONATES [J].

DEMARQUEZ, JL ;

GALPERINE, R ;

BILLEAUD, C ;

BRACHETLIERMAIN, A .

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1987, 10 (04) :292-300

[6] THIOPENTONE INDUCED COMA AFTER SEVERE BIRTH ASPHYXIA [J].

EYRE, JA ;

WILKINSON, AR .

ARCHIVES OF DISEASE IN CHILDHOOD, 1986, 61 (11) :1084-1089

[7] EFFICACY OF PHENOBARBITAL MONOTHERAPY IN TREATMENT OF NEONATAL SEIZURES - RELATIONSHIP TO BLOOD-LEVELS [J].

GAL, P ;

TOBACK, J ;

BOER, HR ;

ERKAN, NV ;

WELLS, TJ .

NEUROLOGY, 1982, 32 (12) :1401-1404

[8] PHARMACOKINETICS OF THIOPENTAL IN THE ASPHYXIATED NEONATE [J].

GARG, DC ;

GOLDBERG, RN ;

WOOMING, RB ;

WEIDLER, DJ .

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1988, 11 (04) :213-218

[9]

Gibaldi M., 1982, PHARMACOKINETICS, Vsecond

[10]

GILMAN JT, 1989, PEDIATRICS, V83, P674

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