ENHANCEMENT OF CURRENT INDUCED BY SUPERFUSION OF GABA IN LOCUS-CERULEUS NEURONS BY PENTOBARBITAL, BUT NOT ETHANOL

被引：45

作者：

OSMANOVIC, SS

SHEFNER, SA

机构：

[1] UNIV BELGRADE, DEPT PATHOPHYSIOL, BELGRADE, YUGOSLAVIA

[2] UNIV ILLINOIS, COLL MED, DEPT PHYSIOL & BIOPHYS, CHICAGO, IL 60612 USA

来源：

BRAIN RESEARCH | 1990年 / 517卷 / 1-2期

关键词：

Alcohol; Ethanol; Locus coeruleus; Pentobarbital; Voltage clamp; γ-Aminobutyric acid; γ-Aminobutyric acid[!sub]A[!/sub] receptor;

D O I：

10.1016/0006-8993(90)91044-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

γ-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conductance increase in all LC neurons tested. In contrast, ethanol did not alter the current and conductance increase induced by bath application of GABA to LC neurons. © 1990.

引用

页码：324 / 329

页数：6

共 58 条

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