BOMBESIN MICROINJECTED INTO THE DORSAL VAGAL COMPLEX INHIBITS TRH-STIMULATED GASTRIC CONTRACTILITY IN RATS

被引：15

作者：

HEYMANNMONNIKES, I

LIVINGSTON, EH

TACHE, Y

SIERRA, A

WEINER, H

GARRICK, T

机构：

[1] VET ADM MED CTR, CTR ULCER RES & EDUC, DEPT PSYCHIAT, WILSHIRE & SAWTELLE BLVD, LOS ANGELES, CA 90073 USA

[2] VET ADM MED CTR, DEPT RES, LOS ANGELES, CA 90073 USA

[3] VET ADM WADSWORTH MED CTR, LOS ANGELES, CA 90073 USA

[4] UNIV CALIF LOS ANGELES, SCH MED, BRAIN RES INST, DEPT PSYCHIAT, LOS ANGELES, CA 90073 USA

[5] UNIV CALIF LOS ANGELES, SCH MED, BRAIN RES INST, DEPT MED, LOS ANGELES, CA 90073 USA

来源：

BRAIN RESEARCH | 1990年 / 533卷 / 02期

关键词：

Bombesin; Dorsal vagal complex; Gastric contractility; Thyrotropin-releasing hormone;

D O I：

10.1016/0006-8993(90)91354-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of centrally injected bombesin on central and peripheral stimulated gastric contractility were investigated in fasted urethane-anesthetized rats. Miniature strain gauge force transducers were acutely implanted on the corpus of the stomach and gastric contractility was analyzed by computer. Intracisternal injection of the stable thyrotropin-releasing hormone (TRH)-analog RX 77368 (77 pmol) induced a stimulation of gastric contractility for 40 min. Intracisternal injection of bombesin (62-620 pmol) followed 30 min later by that of RX 77368 resulted in a dose-related inhibition of the TRH-analog-induced gastric contractility. Intracisternal injection of bombesin (620 pmol) did not modify gastric, contractility stimulated by intravenous carbachol. Stimulation of gastric contractility induced by TRH-analog microinjected into the dorsal vagal complex (DVC) was dose-related suppressed by concomitant injections of bombesin (6.2-620 pmol). Neither bombesin alone (6.2 pmol) nor vehicle modified basal gastric contractility. These results demonstrate that bombesin acts within the brain to inhibit vagally stimulated gastric contractility and that the DVC is a sensitive site for bombesin inhibitory action. These findings suggest a possible interaction between TRH and bombesin in the central vagal regulation of gastric contractility. © 1990.

引用

页码：309 / 314

页数：6

共 33 条

[1] Anastasi, Erspamer, Bucci, Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the European amphibiansBombina andAlytes, Experientia, 27, pp. 166-167, (1971)
[2] Garrick, Buack, Bass, Gastric motility is a major factor in cold restraint-induced lesion formation in rats, Am J Physiol, 250, pp. G191-G199, (1986)
[3] Garrick, Buack, Veiseh, Tache, Thyrotropin-releasing hormone (TRH) acts centrally to stimulate gastric contractility in rats, Life Sci., 40, pp. 649-657, (1987)
[4] Garrick, Minor, Buack, Weiner, Guth, Predictable and unpredictable shock stimulates gastric contractility and causes mucosal injury in rats, Behav. Neurosci., 103, (1989)
[5] Garrick, Stephens, Ishikawa, Sierra, Avidan, Weiner, Tache, Medullary sites for TRH analogue stimulation of gastric contractility in the rat, Am J Physiol, 256, pp. G1011-G1015, (1989)
[6] Greeley, Partin, Spanagel, Dinh, Hill, Trowbridge, Salter, Chuo, Thompson, Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species, Regul. Pept., 16, pp. 169-181, (1986)
[7] Heymann-Monnikes, Tache, Livingston, Sierra, Weiner, Garrick, Bombesin microinjected into the dorsal vagal complex (DVC) inhibits TRH-stimulated gastric contractility in the rat, Gastroenterology, 98, (1990)
[8] Hornby, Rossiter, Pineo, Norman, Friedman, Benjamin, Gillis, Thyrotropin-releasing hormone distribution in the vagal nuclei of the cat and physiological effects upon microinjection, Am J Physiol, 257, pp. G454-G462, (1989)
[9] Ishikawa, Tache, Bombesin microinjected into the dorsal vagal complex inhibits vagally stimulated gastric acid secretion in the rat, Regul. Pept., 24, pp. 187-194, (1989)
[10] Kelly, Gastric emptying of liquids and solids: roles of proximal and distal stomach, Am. J. Physiol., 239, pp. 71-76, (1980)

← 1 2 3 4 →