STROMAL CELL-GROWTH AND BLAST COLONY-FORMING CELLS IN AML BONE-MARROW

被引：2

作者：

ELKHATIB, Y ^{[1
]}

GIDALI, J ^{[1
]}

FEHER, I ^{[1
]}

MOD, A ^{[1
]}

POROS, A ^{[1
]}

HOLLAN, S ^{[1
]}

机构：

[1] NATL INST HAEMATOL & BLOOD TRANSFUS, DAROCI UT 24, H-1113 BUDAPEST, HUNGARY

来源：

LEUKEMIA RESEARCH | 1991年 / 15卷 / 11期

关键词：

AML; BONE MARROW STROMAL LAYERS; BLAST COLONY-FORMING CELLS; ADHESIVE PROPERTIES; EXTRACELLULAR MATRIX; HEMATOPOIETIC PROGENITOR CELLS; ACUTE MYELOID-LEUKEMIA; MYELOPROLIFERATIVE DISORDERS; ADHESIVE INTERACTIONS; EXTRACELLULAR-MATRIX; STEM-CELLS; FIBRONECTIN; INVITRO; MICROENVIRONMENT; CULTURE;

D O I：

10.1016/0145-2126(91)90109-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone marrow cells (BMC) from normal donors and from patients with acute myeloid leukaemia (AML) were cultured. Growth kinetics and the efficiency of stromal layers in supporting the adhesion of normal blast-colony forming cells (BL-CFCs) were studied. BMC from treated AML patients formed confluent stromal layers faster than normal BMCs. BL-CFC binding capacity of normal and AML stromal layers did not differ: on normal stromal layers 67.3-147, on AML stromal layers 63-117 colonies per 5 X 10(5) plastic non-adherent BMC were formed. The amount and/or binding capacity of BL-CFCs was found to be normal in two AML patients in complete remission, while a significantly reduced number and/or binding capacity of BL-CFCs was found in AML non-treated patients and in patients within 4 weeks after the last cytostatic course.

引用

页码：1037 / 1041

页数：5

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