THE ROLE OF INSULIN-LIKE GROWTH FACTOR-I (IGF-1) AND IGF BINDING PROTEIN-1 (IGFBP-1) IN THE PATHOGENESIS OF POLYCYSTIC-OVARY-SYNDROME

被引：101

作者：

HOMBURG, R

PARIENTE, C

LUNENFELD, B

JACOBS, HS

机构：

[1] Department of Obstetrics and Gynaecology, Golda Medical Centre, Petah Tikva 49372 Sackler Medical School, Tel-Aviv University

[2] Endocrinology Unit, Sheba Medical Centre, Tel Hashomer

[3] Cobbold Laboratories, University College and Middlesex School of Medicine, Middlesex Hospital, London

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 10期

关键词：

IGF-1; IGF BINDING PROTEIN-1; INSULIN; POLYCYSTIC OVARIES;

D O I：

10.1093/oxfordjournals.humrep.a137577

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The objective of this study was to elucidate the relationship and role of insulin-like growth factor-1 (IGF-1), IGF binding protein-1 (IGFBP-1), insulin and luteinizing hormone (LH) in the pathogenesis of polycystic ovary syndrome (PCOS). In a pilot study, serum concentrations of IGF-1 were determined in women with PCOS (n = 10), hypopituitarism (n = 12) and normal controls (n = 10). In the main study, serum concentrations of IGF-1, IGFBP-1, insulin and LH in women with anovulation associated (n = 23) and not associated (n = 47) with PCOS were determined. Serum concentrations of IGF-1 were not different in women with PCOS, anovulatory non-PCOS and healthy women but were low in those with hypopituitarism. Mean serum IGFBP-1 in PCOS (33.8 +/- 21.2 mug/1) was decreased compared with anovulatory non-PCOS (60.0 +/- 22 mug/1) (P = 0.0001), and correlated negatively with insulin concentrations (r = -0.67, P = 0.0006). Patients with PCOS could be separated into those with high LH and those with high insulin levels. It was concluded that women with PCOS have normal serum IGF-1 concentrations but IGFBP-1 levels, regulated by insulin, are low. Hyperinsulinaemia and raised LH are independently capable of stimulating ovarian androgen production. Growth factors may have an important role in the pathogenesis of PCOS.

引用

页码：1379 / 1383

页数：5

共 29 条

[1] Adams J., Poison D.W., Abdulwahid N., Morris D.V., Franks S., Mason H.D., Tucker M., Price J., Jacobs H.S., Multifollicular ovaries: Clinical and endocrine features and response to pulsatile gonadotrophin-releasing hormone, Lancet, 2, pp. 1375-1378, (1985)
[2] Adashi E.Y., Resnick C.E., D'Ercole A.J., Svoboda M.E., Van Wyck J.J., Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function, Endocr. Rev, 6, pp. 400-420, (1985)
[3] Antilla L., Ding Y.Q., Ruutianen K., Erkkola R., Iijala K., Huhtaniemi I., Clinical features and circulating gonadotropin, insulin, and androgen interactions in women with polycystic ovarian disease, Fertil. Steril, 55, pp. 1057-1061, (1991)
[4] Barbieri R.L., Makris A., Ryan K.J., Effects of insulin on steroidogenesis in cultured porcine ovarian theca, Fertil. Steril, 40, pp. 237-241, (1983)
[5] Cara J.F., Rosenfield R.L., Somatomedin-C/insulin-like growth factor-1 (IGF-1) enhances LH binding to rat ovarian theca- intersutial (TT) cells, Clin. Res, 901A, (1988)
[6] Cara J.F., Rosenfield R.L., Insulin-like growth factor 1 and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells, Endocrinology, 12, pp. 733-739, (1988)
[7] Ceda G.P., Davis R.G., Rosenfield R.G., Hoffman A.R., The growth hormone (GH)-releasing hormone (GHRH)-GH-somatomedin axis: Evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors 1 and 2, Endocrinology, 12, pp. 1658-1662, (1987)
[8] Chang R.J., Geffner M.E., Associated non-ovarian problems of polycystic ovarian disease: Insulin resistance, Clin. Obstet. Gynecol, 12, pp. 675-685, (1985)
[9] Conway G.S., Jacobs H.S., Holly J.M.P., Wass J.A.H., Effects of luteinizing hormone, insulin, insulin-like growth factor-1 and insulin-like growth factor small binding protein 1 in the polycystic ovary syndrome, Clin. Endocrinol. (Oxf.), 33, pp. 593-603, (1990)
[10] Dale P.O., Tanbo T., Vaaler S., Abyholm T., The impact of body weight and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome, Gynecol. Endocrinol, 6, (1992)

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