TISSUE-SPECIFIC LOCALIZATION OF MITOCHONDRIAL IMIDAZOLINE-GUANIDINIUM RECEPTIVE SITES

被引：34

作者：

TESSON, F ^{[1
]}

LIMON, I ^{[1
]}

PARINI, A ^{[1
]}

机构：

[1] CHU NECKER,PHARMACOL LAB,CNRS,URA 1482,156 RUE VAUGIRARD,F-75015 PARIS,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 02期

关键词：

IDAZOXAN; MITOCHONDRIA; (RABBIT); (HUMAN);

D O I：

10.1016/0014-2999(92)90316-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present report, we studied the distribution of the imidazoline-guanidinium receptive site in mitochondrial fractions from different rabbit and human tissues. Binding studies of the imidazoline-guanidinium receptive site ligand [H-3]idazoxan, allowed to distinguish two groups of tissues: the first one, including kidney, brain and liver, displays a high density of imidazoline-guanidinium receptive site; the second one, consisting of striated and smooth muscle, enterocytes, lung, spleen and heart, is characterized by 4- to 16-fold lower binding site density. The demonstration that mitochondrial imidazoline-guanidinium receptive sites are not equally expressed in all tissues can be considered as a-further progress towards the characterization of their functional activity.

引用

页码：335 / 338

页数：4

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