AMPLIFICATION OF A PARTICULAR DNA-SEQUENCE IN STREPTOMYCES-AMBOFACIENS RP181110 REVERSIBLY PREVENTS SPIRAMYCIN PRODUCTION

被引:14
作者
DARY, A [1 ]
BOURGET, N [1 ]
GIRARD, N [1 ]
SIMONET, JM [1 ]
DECARIS, B [1 ]
机构
[1] UNIV NANCY 1,FAC SCI,GENET & MICROBIOL LAB,BP 239,BLVD AIGUILLETTES,F-54506 VANDOEUVRE NANCY,FRANCE
关键词
SPIRAMYCIN; DNA; AMPLIFICATION; GENOME INSTABILITY; REGULATED PRODUCTION;
D O I
10.1016/0923-2508(92)90039-Q
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Streptomyces ambofaciens RP181110 produces the macrolide antibiotic spiramycin. After treatment with ethidium bromide, 7 strains presenting an amplified sequence of DNA (ADS) were found in its progeny. These ADS were localized within the same amplifiable region of the RP181110 genome. It has been established that these amplified strains were non-producers (Spi-) and that the loss of one particular ADS was correlated with restoration of spiramycin production. Genome rearrangements such as deletions were detected on the same side of the amplifiable region in both amplified and deamplified strains.
引用
收藏
页码:99 / 112
页数:14
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