MONITORING THE ACTIVITY OF ANTIVIRAL THERAPY FOR HIV-INFECTION USING A POLYMERASE CHAIN-REACTION METHOD COUPLED WITH REVERSE TRANSCRIPTION

被引：20

作者：

KOJIMA, E

SHIRASAKA, T

ANDERSON, B

CHOKEKIJCHAI, S

SEI, S

YARCHOAN, R

MITSUYA, H

机构：

[1] NCI,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892

[2] NCI,MED BRANCH,RETROVIRAL DIS SECT,BETHESDA,MD 20892

[3] NCI,PEDIAT BRANCH,INFECT DIS SECT,BETHESDA,MD 20892

来源：

AIDS | 1993年 / 7卷

关键词：

HIV-1; VIRAL LOAD; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; DRUG RESISTANCE; POL GENE MUTATION;

D O I：

10.1097/00002030-199311002-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: To monitor the anti-HIV-1 activity of antiretroviral agents in patients with HIV-1 infection. Method: Quantification of viral RNA copy in plasma or serum using a polymerase chain reaction method coupled with reverse transcription. Conclusions: The HIV-1 RNA copy number represents the HIV-1 viremia status in patients with HIV-1 infection. This copy number is likely to be useful in monitoring the effectiveness of antiviral therapy and the method is likely to be built into every clinical trial of anti-HIV-1 therapy in the near future.

引用

页码：S101 / S105

页数：5

共 16 条

[11] CLINICAL CORRELATES OF INVITRO HIV-1 RESISTANCE TO ZIDOVUDINE - RESULTS OF THE MULTICENTER CANADIAN AZT TRIAL [J].

MONTANER, JSG ;

SINGER, J ;

SCHECHTER, MT ;

RABOUD, JM ;

TSOUKAS, C ;

OSHAUGHNESSY, M ;

RUEDY, J ;

NAGAI, K ;

SALOMON, H ;

SPIRA, B ;

WAINBERG, MA .

AIDS, 1993, 7 (02) :189-196

[12] HIGH-LEVELS OF HIV-1 IN PLASMA DURING ALL STAGES OF INFECTION DETERMINED BY COMPETITIVE PCR [J].

PIATAK, M ;

SAAG, MS ;

YANG, LC ;

CLARK, SJ ;

KAPPES, JC ;

LUK, KC ;

HAHN, BH ;

SHAW, GM ;

LIFSON, JD .

SCIENCE, 1993, 259 (5102) :1749-1754

[13] CHANGES IN DRUG SENSITIVITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DURING THERAPY WITH AZIDOTHYMIDINE, DIDEOXYCYTIDINE, AND DIDEOXYINOSINE - AN INVITRO COMPARATIVE-STUDY [J].

SHIRASAKA, T ;

YARCHOAN, R ;

OBRIEN, MC ;

HUSSON, RN ;

ANDERSON, BD ;

KOJIMA, E ;

SHIMADA, T ;

BRODER, S ;

MITSUYA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :562-566

[14] RESISTANCE TO DDI AND SENSITIVITY TO AZT INDUCED BY A MUTATION IN HIV-1 REVERSE-TRANSCRIPTASE [J].

STCLAIR, MH ;

MARTIN, JL ;

TUDORWILLIAMS, G ;

BACH, MC ;

VAVRO, CL ;

KING, DM ;

KELLAM, P ;

KEMP, SD ;

LARDER, BA .

SCIENCE, 1991, 253 (5027) :1557-1559

[15] HIV-1 SENSITIVITY TO ZIDOVUDINE AND CLINICAL OUTCOME IN CHILDREN [J].

TUDORWILLIAMS, G ;

STCLAIR, MH ;

MCKINNEY, RE ;

MAHA, M ;

WALTER, E ;

SANTACROCE, S ;

MINTZ, M ;

ODONNELL, K ;

RUDOLL, T ;

VAVRO, CL ;

CONNOR, EM ;

WILFERT, CM .

LANCET, 1992, 339 (8784) :15-19

[16]

YARCHOAN R, 1993, IN PRESS J INFECT DI

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