THE STRUCTURE AND FUNCTION OF YEAST ARS ELEMENTS

被引：195

作者：

NEWLON, CS ^{[1
]}

THEIS, JF ^{[1
]}

机构：

[1] UMD, NEW JERSEY MED SCH, NEWARK, NJ USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(05)80094-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past year has seen significant advances in our understanding of the structure and function of yeast ARS elements. These elements, some of which function as chromosomal origins of DNA replication, are modular in structure. An essential domain, the ARS consensus sequence, binds a multiprotein complex that might be the long-sought initiator protein. The flanking domain contains a DNA unwinding element and a binding site for a multifunctional protein that acts as a replication enhancer.

引用

收藏

页码：752 / 758

页数：7

相关论文

共 51 条

[11] THE EFFECT ON CHROMOSOME STABILITY OF DELETING REPLICATION ORIGINS [J].

DERSHOWITZ, A ;

NEWLON, CS .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (01) :391-398

[12] THE ARS CONSENSUS SEQUENCE IS REQUIRED FOR CHROMOSOMAL ORIGIN FUNCTION IN SACCHAROMYCES-CEREVISIAE [J].

DESHPANDE, AM ;

NEWLON, CS .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (10) :4305-4313

[13] PROTEIN DNA INTERACTIONS AT A YEAST REPLICATION ORIGIN [J].

DIFFLEY, JFX ;

COCKER, JH .

NATURE, 1992, 357 (6374) :169-172

[14] PURIFICATION OF A YEAST PROTEIN THAT BINDS TO ORIGINS OF DNA-REPLICATION AND A TRANSCRIPTIONAL SILENCER [J].

DIFFLEY, JFX ;

STILLMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2120-2124

[15] GLOBAL REGULATORS OF CHROMOSOME FUNCTION IN YEAST [J].

DIFFLEY, JFX .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1992, 62 (1-2) :25-33

[16] EVIDENCE SUGGESTING THAT THE ARS ELEMENTS ASSOCIATED WITH SILENCERS OF THE YEAST MATING-TYPE LOCUS HML DO NOT FUNCTION AS CHROMOSOMAL DNA-REPLICATION ORIGINS [J].

DUBEY, DD ;

DAVIS, LR ;

GREENFEDER, SA ;

ONG, LY ;

ZHU, JG ;

BROACH, JR ;

NEWLON, CS ;

HUBERMAN, JA .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (10) :5346-5355

[17] AT LEAST 3 DISTINCT PROTEINS ARE NECESSARY FOR THE RECONSTITUTION OF A SPECIFIC MULTIPROTEIN COMPLEX AT A EUKARYOTIC CHROMOSOMAL ORIGIN OF REPLICATION [J].

ESTES, HG ;

ROBINSON, BS ;

EISENBERG, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (23) :11156-11160

[18] A YEAST ORIGIN OF REPLICATION IS ACTIVATED LATE IN S-PHASE [J].

FERGUSON, BM ;

BREWER, BJ ;

REYNOLDS, AE ;

FANGMAN, WL .

CELL, 1991, 65 (03) :507-515

[19] A POSITION EFFECT ON THE TIME OF REPLICATION ORIGIN ACTIVATION IN YEAST [J].

FERGUSON, BM ;

FANGMAN, WL .

CELL, 1992, 68 (02) :333-339

[20] THE MULTIFUNCTIONAL PROTEIN OBF1 IS PHOSPHORYLATED AT SERINE AND THREONINE RESIDUES IN SACCHAROMYCES-CEREVISIAE [J].

FRANCESCONI, SC ;

EISENBERG, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4089-4093

← 1 2 3 4 5 6 →