CALORIC RESTRICTION PROFOUNDLY INHIBITS LIVER-TUMOR FORMATION AFTER INITIATION BY 6-NITROCHRYSENE IN MALE-MICE

被引：32

作者：

FU, PP

DOOLEY, KL

VONTUNGELN, LS

BUCCI, T

HART, RW

KADLUBAR, FF

机构：

[1] National Center for Toxicological Research, Jefferson

来源：

CARCINOGENESIS | 1994年 / 15卷 / 02期

关键词：

D O I：

10.1093/carcin/15.2.159

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F(1) mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene, These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.

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页码：159 / 161

页数：3

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