共 41 条
EVIDENCE THAT A CENTRAL DOMAIN OF NUCLEOCAPSID PROTEIN IS REQUIRED FOR RNA PACKAGING IN MURINE LEUKEMIA-VIRUS
被引:68
作者:

REIN, A
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA

HARVIN, DP
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA

MIRRO, J
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA

ERNST, SM
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA

GORELICK, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA
机构:
[1] NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, FREDERICK, MD 21702 USA
关键词:
D O I:
10.1128/JVI.68.9.6124-6129.1994
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
We have analyzed RNA packaging by a series of mutants altered in the nucleocapsid (NC) protein of Moloney murine leukemia virus (Mo-MuLV). We found that mutants lacking residues 8 through 11 or 44 through 60 of NC package Mo-MuLV RNA with virtually the same efficiency as wild-type Mo-MuLV. In contrast, point mutants altered at the conserved cysteines in the cysteine array (residues 26 and 29) and a mutant lacking residues 16 through 23 packaged Mo-MuLV RNA with approximately 1% of the efficiency of mild-type Mo-MuLV. The deficiency in packaged RNA was observed not only in Northern (RNA) analysis but also in an RNA-PCR assay, which would detect degraded as well as intact RNA. One of the cysteine array mutants was also shown to be defective with respect to encapsidation of hygromycin phosphotransferase mRNA containing a Mo-MuLV Packaging signal. We suggest that a central region of NC, consisting of the cysteine array and flanking basic residues, is required for RNA packaging in Mo-MuLV.
引用
收藏
页码:6124 / 6129
页数:6
相关论文
共 41 条
[1]
IDENTIFICATION OF A SIGNAL IN A MURINE RETROVIRUS THAT IS SUFFICIENT FOR PACKAGING OF NONRETROVIRAL RNA INTO VIRIONS
[J].
ADAM, MA
;
MILLER, AD
.
JOURNAL OF VIROLOGY,
1988, 62 (10)
:3802-3806

ADAM, MA
论文数: 0 引用数: 0
h-index: 0
机构:
FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST,SEATTLE,WA 98104 FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST,SEATTLE,WA 98104

MILLER, AD
论文数: 0 引用数: 0
h-index: 0
机构:
FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST,SEATTLE,WA 98104 FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST,SEATTLE,WA 98104
[2]
MUTATIONS OF RNA AND PROTEIN SEQUENCES INVOLVED IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PACKAGING RESULT IN PRODUCTION OF NONINFECTIOUS VIRUS
[J].
ALDOVINI, A
;
YOUNG, RA
.
JOURNAL OF VIROLOGY,
1990, 64 (05)
:1920-1926

ALDOVINI, A
论文数: 0 引用数: 0
h-index: 0
机构: WHITEHEAD INST BIOMED RES,9 CAMBRIDGE CTR,CAMBRIDGE,MA 02142

YOUNG, RA
论文数: 0 引用数: 0
h-index: 0
机构: WHITEHEAD INST BIOMED RES,9 CAMBRIDGE CTR,CAMBRIDGE,MA 02142
[3]
ENDOGENOUS ORIGIN OF DEFECTIVE RETROVIRUS-LIKE PARTICLES FROM A RECOMBINANT CHINESE-HAMSTER OVARY CELL-LINE
[J].
ANDERSON, KP
;
LOW, MAL
;
LIE, YS
;
KELLER, GA
;
DINOWITZ, M
.
VIROLOGY,
1991, 181 (01)
:305-311

ANDERSON, KP
论文数: 0 引用数: 0
h-index: 0
机构:
GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA

LOW, MAL
论文数: 0 引用数: 0
h-index: 0
机构:
GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA

LIE, YS
论文数: 0 引用数: 0
h-index: 0
机构:
GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA

KELLER, GA
论文数: 0 引用数: 0
h-index: 0
机构:
GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA

DINOWITZ, M
论文数: 0 引用数: 0
h-index: 0
机构:
GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA GENENTECH INC, DEPT SAFETY EVALUAT, San Francisco, CA 94080 USA
[4]
AVIAN RETROVIRAL RNA ENCAPSIDATION - REEXAMINATION OF FUNCTIONAL 5' RNA SEQUENCES AND THE ROLE OF NUCLEOCAPSID CYS-HIS MOTIFS
[J].
ARONOFF, R
;
HAJJAR, AM
;
LINIAL, ML
.
JOURNAL OF VIROLOGY,
1993, 67 (01)
:178-188

ARONOFF, R
论文数: 0 引用数: 0
h-index: 0
机构: FRED HUTCHINSON CANC RES CTR, DIV BASIC SCI, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA

HAJJAR, AM
论文数: 0 引用数: 0
h-index: 0
机构: FRED HUTCHINSON CANC RES CTR, DIV BASIC SCI, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA

LINIAL, ML
论文数: 0 引用数: 0
h-index: 0
机构: FRED HUTCHINSON CANC RES CTR, DIV BASIC SCI, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA
[5]
SPECIFIC BINDING OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GAG POLYPROTEIN AND NUCLEOCAPSID PROTEIN TO VIRAL RNAS DETECTED BY RNA MOBILITY SHIFT ASSAYS
[J].
BERKOWITZ, RD
;
LUBAN, J
;
GOFF, SP
.
JOURNAL OF VIROLOGY,
1993, 67 (12)
:7190-7200

BERKOWITZ, RD
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032

LUBAN, J
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032

GOFF, SP
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032
[6]
TIGHTLY BOUND ZINC IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I, AND OTHER RETROVIRUSES
[J].
BESS, JW
;
POWELL, PJ
;
ISSAQ, HJ
;
SCHUMACK, LJ
;
GRIMES, MK
;
HENDERSON, LE
;
ARTHUR, LO
.
JOURNAL OF VIROLOGY,
1992, 66 (02)
:840-847

BESS, JW
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

POWELL, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

ISSAQ, HJ
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

SCHUMACK, LJ
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

GRIMES, MK
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

HENDERSON, LE
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

ARTHUR, LO
论文数: 0 引用数: 0
h-index: 0
机构:
NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702 NCI,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC DYNCORP,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702
[7]
A STUDY OF THE DIMER FORMATION OF ROUS-SARCOMA VIRUS-RNA AND OF ITS EFFECT ON VIRAL PROTEIN-SYNTHESIS INVITRO
[J].
BIETH, E
;
GABUS, C
;
DARLIX, JL
.
NUCLEIC ACIDS RESEARCH,
1990, 18 (01)
:119-127

BIETH, E
论文数: 0 引用数: 0
h-index: 0
机构: Centre de Recherches de Biochimie, Génétique Cellulaires du CNRS, 31062 Toulouse

GABUS, C
论文数: 0 引用数: 0
h-index: 0
机构: Centre de Recherches de Biochimie, Génétique Cellulaires du CNRS, 31062 Toulouse

DARLIX, JL
论文数: 0 引用数: 0
h-index: 0
机构: Centre de Recherches de Biochimie, Génétique Cellulaires du CNRS, 31062 Toulouse
[8]
EFFECT OF REARRANGEMENTS AND DUPLICATIONS OF THE CYS-HIS MOTIFS OF ROUS-SARCOMA VIRUS NUCLEOCAPSID PROTEIN
[J].
BOWLES, NE
;
DAMAY, P
;
SPAHR, PF
.
JOURNAL OF VIROLOGY,
1993, 67 (02)
:623-631

BOWLES, NE
论文数: 0 引用数: 0
h-index: 0

DAMAY, P
论文数: 0 引用数: 0
h-index: 0

SPAHR, PF
论文数: 0 引用数: 0
h-index: 0
[9]
EXTENDED X-RAY ABSORPTION FINE-STRUCTURE STUDIES OF A RETROVIRUS - EQUINE INFECTIOUS-ANEMIA VIRUS CYSTEINE ARRAYS ARE COORDINATED TO ZINC
[J].
CHANCE, MR
;
SAGI, I
;
WIRT, MD
;
FRISBIE, SM
;
SCHEURING, E
;
CHEN, E
;
BESS, JW
;
HENDERSON, LE
;
ARTHUR, LO
;
SOUTH, TL
;
PEREZALVARADO, G
;
SUMMERS, MF
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1992, 89 (21)
:10041-10045

CHANCE, MR
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

SAGI, I
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

WIRT, MD
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

FRISBIE, SM
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

SCHEURING, E
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

CHEN, E
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

BESS, JW
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

HENDERSON, LE
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

ARTHUR, LO
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

SOUTH, TL
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

PEREZALVARADO, G
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA

SUMMERS, MF
论文数: 0 引用数: 0
h-index: 0
机构: GEORGETOWN UNIV, DEPT CHEM, WASHINGTON, DC 20057 USA
[10]
CIS ELEMENTS AND TRANS-ACTING FACTORS INVOLVED IN THE RNA DIMERIZATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS HIV-1
[J].
DARLIX, JL
;
GABUS, C
;
NUGEYRE, MT
;
CLAVEL, F
;
BARRESINOUSSI, F
.
JOURNAL OF MOLECULAR BIOLOGY,
1990, 216 (03)
:689-699

DARLIX, JL
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,RETROVIRUS LAB,F-75724 PARIS 15,FRANCE

GABUS, C
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,RETROVIRUS LAB,F-75724 PARIS 15,FRANCE

NUGEYRE, MT
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,RETROVIRUS LAB,F-75724 PARIS 15,FRANCE

CLAVEL, F
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,RETROVIRUS LAB,F-75724 PARIS 15,FRANCE

BARRESINOUSSI, F
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,RETROVIRUS LAB,F-75724 PARIS 15,FRANCE