A HISTOCHEMICAL STUDY OF EXPERIMENTALLY INDUCED MALIGNANT SKIN TUMOURS

被引：8

作者：

DIENGDOH, JV

CHAYEN, J

机构：

[1] Department of Immunology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, London

[2] Division of Cellular Biology, The Mathilda and Terence Kennedy, Institute of Rheumatology, London

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1969年 / 81卷 / 11期

关键词：

D O I：

10.1111/j.1365-2133.1969.tb15953.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

SUMMARY.— The histochemistry of benzpyrene‐induced malignant skin tumours has been studied. The metabolism of these cells appeared to involve suppression of the succinic dehydrogenase‐cytochrome oxidase system; enhanced activity for enzymes of the pentose cycle and increased reaction for enzymes associated with the glycolytic pathway. The inhibition of the “succinoxidase” system has been discussed in relation to the possibility of deletion of the enzyme system by the carcinogen. This might result in the release of the metabolism of these cells from the normal regulatory control of the cytochrome pathway thus producing an enhancement of the growth potential of these cells. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：835 / &

共 7 条

[1] OXIDATION OF L-ASCORBIC ACID BY CELLS OF CARCINOMA OF HUMAN CERVIX [J].