Twenty-two well known drugs, covering a wide range of pharmacological types, have been examined for their ability to affect the hemolysis of rat erythrocytes induced by hypotonicity, deoxycholate and digitonin. Chlorpromazine, chlorprothixene, phenindamine, desipramine, imipramine and chloroquine enhanced deoxycholate-induced hemolysis and depressed hypotonie hemolysis at low concentrations while stimulating it at high concentrations. Debrisoquin, guanethidine, tripelennamine, leverphanol and cocaine, protected against hypotonie and enhanced deoxycholateinduced hemolysis. Acetylsalicylic acid, indomethacin, chlordiazepoxide, cortisol, cortisone, deoxycorticosterone, hydrochlorothiazide, acetazolamide and prostigmine protected against hypotonie hemolysis without affecting other systems. Digitonininduced hemolysis was least affected by these drugs. Ethacrynic acid was unique, even among other diuretics, ir protecting against deoxycholate- and digitonin-induced hemolysis. Ouabain was also unique in its complete inactivity in the three hemolytic systems. No correlation could be found between the pharmacological and membrane effects. © 1969.
