GLUTATHIONE CONJUGATION IN THE DETOXICATION OF (Z)-1,3-DICHLOROPROPENE (A COMPONENT OF THE NEMATOCIDE D-D) IN THE RAT

1. (Z)-1,3-Dichloro[2-14C]propene([14C](Z)-DCP) when dosed orally to rats gave 82-84% of the radioactivity in the urine 24 h after treatment. Most of this 14C (92% was present as N-acetyl-S-((Z)-3-chloroprop-2-enyl)cysteine ((Z)-DCP mercapturic acid). 2. When (Z)-DCP was incubated with glutathione and rat liver cytosol (containing glutathione S-alkyl transferase), very rapid loss of (Z)-DCP was observed. The product of this reaction was S-[(Z)-3-chloroprop-2-enyl)]glutathione. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.