ADVERSE REACTIONS TO FRUSEMIDE IN HOSPITAL INPATIENTS

被引:46
作者
LOWE, J [1 ]
GRAY, J [1 ]
HENRY, DA [1 ]
LAWSON, DH [1 ]
机构
[1] GLASGOW ROYAL INFIRM,PROGRAMME DRUG SURVEILLANCE,GLASGOW G4 0SF,SCOTLAND
关键词
D O I
10.1136/bmj.2.6186.360
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Out of 2580 medical inpatients included in a drug-surveillance programme, 585 (22.7%) were treated with frusemide. Of these, 123 (21.0%) had a total of 177 adverse reactions. The most common were hypovolaemia (85 cases), hyperuricaemia (54), and hypokalaemia (21). Most reactions were mild, and only three patients had potentially life-threatening effects. The incidence of adverse reactions increased significantly with daily dose, occurring in 47 patients (13.5%) given up to 40 mg, 42 (26.3%) given up to 80 mg, and 34 (43.6%) given over 80 mg (P <0.001). There was no clear association between side effects and a raised blood urea concentration on admission, confirming that treatment with frusemide is not more hazardous in patients with renal failure. Frusemide is a safe and highly effective diuretic. Nevertheless, in view of the potential seriousness of volume depletion, dosage should probably begin at 20 rather than 40 mg daily. © 1979, British Medical Journal Publishing Group. All rights reserved.
引用
收藏
页码:360 / 362
页数:3
相关论文
共 13 条
[1]  
BRYANT JM, 1962, AM J MEDICINE, V33, P400
[2]  
GOODMAN LS, 1975, PHARMACOLOGICAL BASI
[3]   CLINICAL TOXICITY OF FUROSEMIDE IN HOSPITALIZED-PATIENTS - REPORT FROM BOSTON COLLABORATIVE DRUG SURVEILLANCE PROGRAM [J].
GREENBLATT, DJ ;
DUHME, DW ;
ALLEN, MD ;
KOCHWESER, J .
AMERICAN HEART JOURNAL, 1977, 94 (01) :6-13
[4]   HOSPITAL ADMISSIONS DUE TO ADVERSE DRUG-REACTIONS [J].
HUTCHEON, AW ;
LAWSON, DH ;
JICK, H .
JOURNAL OF CLINICAL PHARMACY, 1978, 3 (04) :219-224
[5]   COMPREHENSIVE DRUG SURVEILLANCE [J].
JICK, H ;
MIETTINEN, OS ;
SHAPIRO, S ;
LEWIS, GP ;
SISKIND, V ;
SLONE, D .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1970, 213 (09) :1455-+
[6]   DIURETICS AND POTASSIUM METABOLISM - REASSESSMENT OF NEED, EFFECTIVENESS AND SAFETY OF POTASSIUM THERAPY [J].
KASSIRER, JP ;
HARRINGTON, JT .
KIDNEY INTERNATIONAL, 1977, 11 (06) :505-515
[7]   ACQUIRED EPIDERMOLYSIS BULLOSA DUE TO HIGH-DOSE FRUSEMIDE [J].
KENNEDY, AC ;
LYELL, A .
BRITISH MEDICAL JOURNAL, 1976, 1 (6024) :1509-1510
[8]  
LAWSON DH, 1974, Q J MED, V43, P433
[9]   DRUG SURVEILLANCE FOR ADVERSE DRUG EFFECTS - STUDY OF MEDICAL INPATIENTS [J].
LAWSON, DH ;
JICK, H .
JOURNAL OF CLINICAL PHARMACY, 1978, 3 (03) :203-210
[10]  
LAWSON DH, 1976, Q J MED, V45, P469