EFFECT OF MEMBRANE PHASE-TRANSITION ON LONG-TIME CALCIUM-INDUCED FUSION OF PHOSPHATIDYLSERINE VESICLES

被引：4

作者：

LEUNG, SO

HO, JT

机构：

[1] Department of Physics and Astronomy, State University of New York at Buffalo, Buffalo

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1991年 / 57卷 / 01期

关键词：

DYNAMIC LIGHT SCATTERING; FUSION; CALCIUM; PHOSPHATIDYLSERINE; PHASE TRANSITION; VESICLES;

D O I：

10.1016/0009-3084(91)90055-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dynamic light scattering has been used to study the temperature dependence of the extent of long-time calcium-induced fusion of sonicated vesicles composed of various natural and synthetic phosphatidylserine with different acyl chains. The vesicles of each composition are found to exhibit a peak temperature in the vicinity of which the extent of fusion shows a distinct maximum. The fusion peak temperature increases as the bilayer gel-to-liquid-crystal phase transition temperature increases. The results suggest a role played by membrane fluidity in determining fusion efficiency.

引用

页码：103 / 107

页数：5

共 9 条

[1] TEMPERATURE-DEPENDENCE OF DIVALENT-CATION INDUCED FUSION OF PHOSPHATIDYLSERINE LIPOSOMES - EVALUATION OF THE KINETIC RATE CONSTANTS [J].