STUDIES ON THE POLAROGRAPHIC-BEHAVIOR OF ESTAZOLAM

In 0.1M NH3-NH4Cl buffer (pH 9.2) a sensitive 2-electron reduction wave of estazolam is obtained by single-sweep oscillopolarography. The peak potential is -1.08 V (vs. SCE). The peak height is proportional to the concentration of estazolam over the range 1.0 × 10-7-9.0 × 10∂M. The detection limit is 5.0 × 10-8M. The behaviour of the reduction wave has been studied and applied to the determination of estazolam. The reduction process is irreversible and the wave shows adsorptive characteristics, the behaviour obeying the Frumkin adsorption isotherm. The adsorption coefficient β is 1.16 × 106 1./mole and the interaction factor α is -1.06. The mechanism of the electrode reaction is discussed. © 1990.