DYNAMIC SIGNAL INTENSITY CHANGES IN LIVER WITH SUPERPARAMAGNETIC MR CONTRAST AGENTS

被引：26

作者：

REIMER, P ^{[1
]}

KWONG, KK ^{[1
]}

WEISSKOFF, R ^{[1
]}

COHEN, MS ^{[1
]}

BRADY, TJ ^{[1
]}

WEISSLEDER, R ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT RADIOL,CTR NUCL MAGNET RESONANCE,BLDG 149,13TH ST,BOSTON,MA 02129

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1992年 / 2卷 / 02期

关键词：

CONTRAST ENHANCEMENT; CONTRAST MEDIA; COMPARATIVE STUDIES; EXPERIMENTAL STUDIES; IRON; LIVER; MR;

D O I：

10.1002/jmri.1880020210

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The dynamic effects of three different superparamagnetic magnetic resonance (MR) contrast agents on liver signal were evaluated with an echo-planar imaging technique. The contrast agents were (a) USPIO (ultrasmall superparamagnetic iron oxide), which has a long blood half-life and was developed for MR imaging of lymph nodes and bone marrow; (b) AG (arabino-galactan)-USPIO, an asialoglycoprotein receptor-directed iron oxide with hepatocyte uptake; and (c) AMI-25, a conventional reticuloendothelial iron oxide agent. Dynamic liver signal intensity (SI) curves reflect different uptake mechanisms for the different agents. Receptor blocking experiments indicate that intracellular redistribution or clustering of the AG-USPIO (known to occur from electron microscopy studies) does not contribute to the decrease in liver SI. Monitoring liver SI over time with echo-planar imaging may provide a better understanding of the kinetics of the growing number of MR contrast agents and allow optimization of imaging protocols to exploit peak enhancement.

引用

页码：177 / 181

页数：5

共 23 条

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