TISSUE DISTRIBUTION AND ANTILEISHMANIAL ACTIVITY OF LIPOSOMISED AMPHOTERICIN-B IN BALB/C MICE

被引：10

作者：

AHMAD, I

AGARWAL, A

PAL, A

GURU, PY

BACHHAWAT, BK

GUPTA, CM

机构：

[1] CENT DRUG RES INST,DIV MEMBRANE BIOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] CENT DRUG RES INST,DIV PARASITOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

[3] UNIV DELHI,LIPOSOME RES CTR,NEW DELHI 110021,INDIA

来源：

JOURNAL OF BIOSCIENCES | 1991年 / 16卷 / 04期

关键词：

AMPHOTERICIN-B; ANTILEISHMANIAL ACTIVITY; RENAL TOXICITY; LIPOSOMES; TISSUE DISTRIBUTION; DRUG DELIVERY;

D O I：

10.1007/BF02703287

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antileishmanial activity and organ distribution of the antifungal drug Amphotericin-B in free and liposomised form have been studied in Balb/c mice infected with Leishmania donovani. Results indicate that Amphotericin-B in the liposomised form is significantly more active than the free form. This increase in the activity is perhaps related to the reduced drug toxicity rather than the altered drug distribution at the site of infection.

引用

页码：217 / 221

页数：5

共 13 条

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