DIFFERENTIATION INDUCTION IN HUMAN BREAST-TUMOR CELLS BY OKADAIC ACID AND RELATED INHIBITORS OF PROTEIN PHOSPHATASES-1 AND PHOSPHATASES-2A

被引：28

作者：

KIGUCHI, K ^{[1
]}

GIOMETTI, C ^{[1
]}

CHUBB, CH ^{[1
]}

FUJIKI, H ^{[1
]}

HUBERMAN, E ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,TOKYO 104,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90209-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Okadaic acid (OA), an inhibitor of protein phosphatases 1 and 2A, induces differentiation in human MCF-7, AU-565, and MB-231 breast tumor cells. In MCF-7 cells, OA elicited within 5 min an increase in the levels of a set of phosphorylated cellular proteins, within hours expression of the early response genes junB, c-jun, and c-fos, and within days manifestation of differentiation. Differentiation was also induced by two related protein phosphatase inhibitors, but not by an inactive OA derivative or by an inhibitor that penetrates epithelial cells poorly. These results indicate that OA and related agents can induce tumor breast cell differentiation, and this induction is correlated with their ability to inhibit PPH 1 and 2A. © 1992.

引用

页码：1261 / 1267

页数：7

共 23 条

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