CYLINDRAMIDE - CYTOTOXIC TETRAMIC ACID LACTAM FROM THE MARINE SPONGE HALICHONDRIA-CYLINDRATA TANITA AND HOSHINO

被引：88

作者：

KANAZAWA, S ^{[1
]}

FUSETANI, N ^{[1
]}

MATSUNAGA, S ^{[1
]}

机构：

[1] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)77493-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cytotoxic tetramic acid lactam named cylindramide (1) has been isolated from the marine sponge Halichondria cylindrata. The structure was determined by interpretation of 2D NMR spectra as a macrocyclic lactam including an acyltetramic acid and a trisubstituted bicyclo[3.3.0]octene. This lactam was cytotoxic against B16 melanoma cells with an IC50 Of 0.8 mug/mL.

引用

页码：1065 / 1068

页数：4

共 13 条

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