INDOLE ALKALOIDS - A COMBINED CHEMICAL AND ENZYMATIC ROUTE FOR EBURNANE RING CONSTRUCTION - FORMAL SYNTHESIS OF (-)-EBURNAMONINE

被引：19

作者：

PALMISANO, G

DANNIBALLE, P

SANTAGOSTINO, M

机构：

[1] Dipartimento di Chimica Organica e Industriale, Facoltá di Scienze, Università degli Studi di Milano, 20133 Milano

来源：

TETRAHEDRON | 1994年 / 50卷 / 31期

关键词：

D O I：

10.1016/S0040-4020(01)85522-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled formal synthesis of(-)-eburnamonine 1, a tetracyclic indole alkaloid used as antihypertensive drug, has been achieved through the use of [3,3]-sigmatropic rearrangement (Claisen rearrangement) of the enantiopure beta-alkoxy acrylate 4, available from rac-3-ethylcyclohexenol 3 via lipase-catalyzed transesterification

引用

页码：9487 / 9494

页数：8

共 31 条

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