INFLUENCE OF TIME, TEMPERATURE AND ANTICOAGULANTS ON THE DETERMINATION OF T-PA ACTIVITY

被引：1

作者：

ERIKSSON, E

SODERBERG, R

RISBERG, B

机构：

[1] Dept. of Surgery, The University of Gothenburg

来源：

FIBRINOLYSIS | 1994年 / 8卷

关键词：

TISSUE-TYPE PLASMINOGEN ACTIVATOR; BLOOD HANDLING; PLASMA PREPARATION;

D O I：

10.1016/0268-9499(94)90280-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In blood both tissue-type plasminogen activator (t-PA) and its fast acting inhibitor PAI-1 are present. Upon blood collection and plasma preparation the reaction between these components is still possible, leading to an erroneously low determination of t-PA activity. In this study the effect of handling speed, temperature and anticoagulant on the measured t-PA activity is determined. It was found that handling speed, temperature and type of anticoagulant and PAI-1 level have influence on the t-PA activity measured. Rapid acidification appears the method of choice: Stabilyte vacutainers are the most suitable way for blood collection for t-PA activity measurement.

引用

页码：150 / 151

页数：2